Section edited by Frank Eisenhaber and Sandor Pongor

The Bioinformatics section will be the publishing channel for scientific articles that report about theoretical, computational and data analysis approaches applied to biological, medical and other life science related problems, and the results and insights that have been achieved with them. Special emphasis is given to manuscripts that deal with biological mechanism interpretation to biomolecular sequence data and data from other experimental high-throughput techniques. This section also covers all fields of bioinformatics and computational biology that might not be handled by other subsections of Biology Direct. Hypotheses are welcome as long as they are based on rigorous scientific standards and as they fit existing data. Manuscripts describing new methods or software developments need to demonstrate that a major improvement has been achieved, and this has led to either improved accuracy by orders of magnitude, lowered resource consumption and/or some new biological insight.

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  1. Discovery notes

    Intrinsic protein disorder in histone lysine methylation

    Histone lysine methyltransferases (HKMTs), catalyze mono-, di- and trimethylation of lysine residues, resulting in a regulatory pattern that controls gene expression. Their involvement in many different cellul...

    Tamas Lazar, Eva Schad, Beata Szabo, Tamas Horvath, Attila Meszaros, Peter Tompa and Agnes Tantos

    Biology Direct 2016 11:30

    Published on: 30 June 2016

  2. Research

    Gene overlapping and size constraints in the viral world

    Viruses are the simplest replicating units, characterized by a limited number of coding genes and an exceptionally high rate of overlapping genes. We sought a unified evolutionary explanation that accounts for...

    Nadav Brandes and Michal Linial

    Biology Direct 2016 11:26

    Published on: 21 May 2016

  3. Application note

    Altools: a user friendly NGS data analyser

    Genotyping by re-sequencing has become a standard approach to estimate single nucleotide polymorphism (SNP) diversity, haplotype structure and the biodiversity and has been defined as an efficient approach to ...

    Salvatore Camiolo, Gaurav Sablok and Andrea Porceddu

    Biology Direct 2016 11:8

    Published on: 17 February 2016

  4. Research

    PEPstrMOD: structure prediction of peptides containing natural, non-natural and modified residues

    In the past, many methods have been developed for peptide tertiary structure prediction but they are limited to peptides having natural amino acids. This study describes a method PEPstrMOD, which is an updated...

    Sandeep Singh, Harinder Singh, Abhishek Tuknait, Kumardeep Chaudhary, Balvinder Singh, S. Kumaran and Gajendra P. S. Raghava

    Biology Direct 2015 10:73

    Published on: 21 December 2015

  5. Review

    RNA motif discovery: a computational overview

    Genomic studies have greatly expanded our knowledge of structural non-coding RNAs (ncRNAs). These RNAs fold into characteristic secondary structures and perform specific-structure dependent biological function...

    Avinash Achar and Pål Sætrom

    Biology Direct 2015 10:61

    Published on: 9 October 2015

  6. Research

    The human disease network in terms of dysfunctional regulatory mechanisms

    Elucidation of human disease similarities has emerged as an active research area, which is highly relevant to etiology, disease classification, and drug repositioning. In pioneer studies, disease similarity wa...

    Jing Yang, Su-Juan Wu, Wen-Tao Dai, Yi-Xue Li and Yuan-Yuan Li

    Biology Direct 2015 10:60

    Published on: 8 October 2015

  7. Review

    Microarray experiments and factors which affect their reliability

    Oligonucleotide microarrays belong to the basic tools of molecular biology and allow for simultaneous assessment of the expression level of thousands of genes. Analysis of microarray data is however very compl...

    Roman Jaksik, Marta Iwanaszko, Joanna Rzeszowska-Wolny and Marek Kimmel

    Biology Direct 2015 10:46

    Published on: 3 September 2015

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