Non-coding DNA and RNA

Section edited by Isidore Rigoutsos

This section focuses on the experimental and computational analysis of non-coding DNA and of the numerous short and long RNAs that are transcribed from the genomes of eukaryotic organisms. Suitable topics include the principles of genomic architecture and organization, intra- and inter-genomic studies of regulatory regions, mechanisms of RNA biogenesis and processing, biochemical and molecular analyses of individual RNAs or of classes of RNAs, elucidation of the molecular interactions between RNAs and their targets, functional examination of the roles of RNAs in the context of a specific cell type or cell state, and system level investigations of currently uncharacterized or poorly characterized categories of RNAs.

  1. Research

    ZFAS1: a long noncoding RNA associated with ribosomes in breast cancer cells

    Most of the eukaryotic genome is transcribed, yielding a complex network of transcripts including thousands of lncRNAs that generally lack protein coding potential. However, only a small percentage of these mo...

    Herah Hansji, Euphemia Y. Leung, Bruce C. Baguley, Graeme J. Finlay, David Cameron-Smith, Vandre C. Figueiredo and Marjan E. Askarian-Amiri

    Biology Direct 2016 11:62

    Published on: 21 November 2016

  2. Comment

    Mammalian Argonaute-DNA binding?

    When a field shares the consensus that a particular phenomenon does NOT occur, this may reflect extensive experimental investigations with negative outcomes, or may represent the “common sense” position based ...

    Neil R Smalheiser and Octavio L A Gomes

    Biology Direct 2014 10:27

    Published on: 4 December 2014

  3. Research

    The human platelet: strong transcriptome correlations among individuals associate weakly with the platelet proteome

    For the anucleate platelet it has been unclear how well platelet transcriptomes correlate among different donors or across different RNA profiling platforms, and what the transcriptomes’ relationship is with t...

    Eric R Londin, Eleftheria Hatzimichael, Phillipe Loher, Leonard Edelstein, Chad Shaw, Kathleen Delgrosso, Paolo Fortina, Paul F Bray, Steven E McKenzie and Isidore Rigoutsos

    Biology Direct 2014 9:3

    Published on: 14 February 2014