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  1. Choriocarcinoma is a malignant cancer that belongs to gestational trophoblastic neoplasia (GTN). Herein, serum metabolomic analysis was performed on 29 GTN patients and 30 healthy individuals to characterize t...

    Authors: Xiao-Mei Liu, Zi-Hao Wang, Qian-Xue Wei, Yang Song and Xiao-Xin Ma
    Citation: Biology Direct 2024 19:78
    Content type: Research Published on:

  2. GALNTs (UDP-GalNAc; polypeptide N-acetylgalactosaminyltransferases) initiate mucin-type O-GalNAc glycosylation by adding N-GalNAc to protein serine/threonine residues. Abnormalities in O-GalNAc glycosylation a...

    Authors: Yuanwen Peng, Jun Liu, Lili Sun, Qiuying Zheng, Can Cao, Wenyong Ding, Shufeng Yang, Li Ma and Wenli Zhang
    Citation: Biology Direct 2024 19:77
    Content type: Research Published on:

  3. Moyamoya disease, characterized by basal cerebral artery obstruction, was studied for differential protein expression to elucidate its pathogenesis. Proteomic analysis of cerebrospinal fluid from 10 patients, ...

    Authors: Dong Guo, Yang Dong, Hongbin Li, Hongwei Li and Bo Yang
    Citation: Biology Direct 2024 19:76
    Content type: Research Published on:

  4. Gastrin is a gastrointestinal peptide hormone that plays an important role in the progression of colorectal cancer (CRC). However, the molecular mechanism remains unclear. In this study, we identified gastrin-...

    Authors: Xu Wang, Tianjiao Sun, Jiapeng Fan, Xueliang Zuo and Jiading Mao
    Citation: Biology Direct 2024 19:75
    Content type: Research Published on:

  5. Excavation of key molecules can help identify therapeutic targets and improve the prognosis of pancreatic cancer. This study evaluated the roles of SUMO3 in cell viability, glycolysis, gemcitabine (GEM) sensit...

    Authors: Liming Zhu, Gang Chen, Changjing Huang, Huifeng Gao, Yilin Wang and Yehua Shen
    Citation: Biology Direct 2024 19:74
    Content type: Research Published on:

  6. Hematopoietic stem cells (HSCs) exhibit significant functional and metabolic alterations within the lung cancer microenvironment, contributing to tumor progression and immune evasion by increasing differentiat...

    Authors: Ziqi Guo, Yaping Liu, Xin Li, Yuying Huang, Zuping Zhou and Cheng Yang
    Citation: Biology Direct 2024 19:73
    Content type: Research Published on:

  7. TSPAN7 is an important factor in tumor progression. However, the precise function of TSPAN7 and its role in pan-cancer are not clear.

    Authors: Bingnan Lu, Yifan Liu, Yuntao Yao, Dawei Zhu, Xiangmin Zhang, Keqin Dong, Xiao Xu, Donghao Lv, Zihui Zhao, Haoyu Zhang, Xinyue Yang, Wenjia Fu, Runzhi Huang, Jianwei Cao, Jian Chu, Xiuwu Pan…
    Citation: Biology Direct 2024 19:72
    Content type: Research Published on:

  8. Kidney renal clear cell carcinoma (KIRC) represents a significant proportion of renal cell carcinomas and is characterized by high aggressiveness and poor prognosis despite advancements in immunotherapy. Disul...

    Authors: Kangjie Xu, Dongling Li, Kangkang Ji, Yanhua Zhang, Minglei Zhang, Hai Zhou, Xuefeng Hou, Jian Jiang, Zihang Zhang, Hua Dai and Hang Sun
    Citation: Biology Direct 2024 19:71
    Content type: Research Published on:

  9. The recombination landscape and subsequent natural selection have vast consequences forevolution and speciation. However, most of the crossover and recombination hotspots are yet to be discovered. We previousl...

    Authors: Mina Ohadi, Masoud Arabfard, Safoura Khamse, Samira Alizadeh, Sara Vafadar, Hadi Bayat, Nahid Tajeddin, Ali M. A. Maddi, Ahmad Delbari and Hamid R. Khorram Khorshid
    Citation: Biology Direct 2024 19:70
    Content type: Research Published on:

  10. A substantive body of evidence has demonstrated the significant roles of circular RNA (circRNA) in cancer. However, the contribution of dysregulated circRNAs to ovarian cancer (OC) remains elusive. We aim to e...

    Authors: Yu Sun, Xiyi Chen, Yaqian Shi, Fang Teng, Chencheng Dai, Lili Ge, Juan Xu and Xuemei Jia
    Citation: Biology Direct 2024 19:69
    Content type: Research Published on:

  11. Cancer-associated fibroblasts (CAFs) have been reported that can affect cancer cell proliferation, metastasis, ferroptosis, and immune escape. METTL3-mediated N6-methyladenine (m6A) modification is involved in...

    Authors: Hongtao Ren, Mincong Wang, Xiulong Ma, Lei An, Yuyan Guo and Hongbing Ma
    Citation: Biology Direct 2024 19:68
    Content type: Research Published on:

  12. The cell and molecular bases of arbuscular mycorrhizal (AM) symbiosis, a crucial plant-fungal interaction for nutrient acquisition, have been extensively investigated by coupling traditional RNA sequencing tec...

    Authors: Sofía Cristina Somoza, Paola Bonfante and Marco Giovannetti
    Citation: Biology Direct 2024 19:67
    Content type: Review Published on:

  13. Breast cancer is the most common cause of death from cancer in women. Here, we present the case of a 43-year-old woman, who received a diagnosis of claudin-low luminal B breast cancer. The lesion revealed to b...

    Authors: Sara Giovannini, Artem Smirnov, Livia Concetti, Manuel Scimeca, Alessandro Mauriello, Julia Bischof, Valentina Rovella, Gerry Melino, Claudio Oreste Buonomo, Eleonora Candi and Francesca Bernassola
    Citation: Biology Direct 2024 19:66
    Content type: Research Published on:

  14. Disulfidptosis is a newly identified mechanism of cell death triggered by disulfide stress. Thus, gaining a comprehensive understanding of the disulfidptosis signature present in gastric cancer (GC) could grea...

    Authors: Zitao Liu, Liang Sun, Wenjie Zhu, Jinfeng Zhu, Changlei Wu, Xingyu Peng, Huakai Tian, Chao Huang and Zhengming Zhu
    Citation: Biology Direct 2024 19:65
    Content type: Research Published on:

  15. It was a Lucky Strike to be working with Eraldo Antonini on hemoglobin and myoglobin when Jeffries Wyman arrived in Rome in 1961. I found myself connected with a number of creative scientists when the concept ...

    Authors: Maurizio Brunori
    Citation: Biology Direct 2024 19:64
    Content type: Review Published on:

  16. Epidermal stem cells (EPSCs) are essential for maintaining skin homeostasis and ensuring a proper wound healing. During in vitro cultivations, EPSCs give rise to transient amplifying progenitors and differentiate...

    Authors: Maria Pia Polito, Alessio Romaldini, Serena Rinaldo and Elena Enzo
    Citation: Biology Direct 2024 19:63
    Content type: Review Published on:

  17. High glucose levels are key factors and key contributors to several cardiovascular diseases associated with cardiomyocyte injury. Ferroptosis, which was identified in recent years, is a mode of cell death caus...

    Authors: Pengfei Wang, Xiaohua Guo, Hongchao Wang, Lijie Wang, Meifang Ma and Bingyan Guo
    Citation: Biology Direct 2024 19:62
    Content type: Research Published on:

  18. Myofibroblast buildup and prostatic fibrosis play a crucial role in the development of benign prostatic hyperplasia (BPH). Treatments specifically targeting myofibroblasts could be a promising approach for tre...

    Authors: Tiewen Li, Yu Zhang, Zeng Zhou, Lvxin Guan, Yichen Zhang, Zhiyuan Zhou, Wenhao Wang, Xuehao Zhou, Di Cui, Chenyi Jiang and Yuan Ruan
    Citation: Biology Direct 2024 19:61
    Content type: Research Published on:

  19. Retrotransposition is one of the main factors responsible for gene duplication and thus genome evolution. However, the sequences that undergo this process are not only an excellent source of biological diversi...

    Authors: Joanna Kozłowska-Masłoń, Joanna Ciomborowska-Basheer, Magdalena Regina Kubiak and Izabela Makałowska
    Citation: Biology Direct 2024 19:60
    Content type: Research Published on:

  21. Cluster of Differentiation 1 (CD1) proteins are widely expressed throughout jawed vertebrates and present lipid antigens to specific CD1-restricted T lymphocytes. CD1 molecules play an important role in immune...

    Authors: Konstantin V. Gunbin, Gelina S. Kopeina, Boris Zhivotovsky and Alexey V. Zamaraev
    Citation: Biology Direct 2024 19:58
    Content type: Research Published on:

  22. Laryngeal carcinoma (LC) is a common cancer of the respiratory tract. This study aims to investigate the role of RNA-binding motif protein 15 (RBM15) in the cisplatin (DDP) resistance of LC cells. LC-DDP-resis...

    Authors: Yue Liang, Haoyue Zhong, Yi Zhao, XiaoMin Tang, Chunchen Pan, Jingwu Sun and Jiaqiang Sun
    Citation: Biology Direct 2024 19:57
    Content type: Research Published on:

  23. Neuroendocrine prostate cancer (NEPC), a lethal subset of prostate cancer (PCa), is characterized by loss of AR signaling and resistance to AR-targeted therapy. While it is well reported that second-generation...

    Authors: Nan Jing, Zhenkeke Tao, Xinxing Du, Zhenzhen Wen, Wei-Qiang Gao, Baijun Dong and Yu-Xiang Fang
    Citation: Biology Direct 2024 19:56
    Content type: Research Published on:

  24. Ubiquitinylation of protein substrates results in various but distinct biological consequences, among which ubiquitin-mediated degradation is most well studied for its therapeutic application. Accordingly, art...

    Authors: Tatyana A. Grigoreva, Daria S. Novikova, Gerry Melino, Nick A. Barlev and Vyacheslav G. Tribulovich
    Citation: Biology Direct 2024 19:55
    Content type: Review Published on:

  25. Retinal vascular endothelial cell (RVECs) injury is a major cause of morbidity and mortality among the patients with diabetes. RVECs dysfunction is the predominant pathological manifestation of vascular compli...

    Authors: Qi Zhou, Min Tian, Yang Cao, Min Tang, Xiaohong Xiang, Lu Guo and Hongbin Lv
    Citation: Biology Direct 2024 19:54
    Content type: Research Published on:

  26. Hepatocellular carcinoma (HCC) ranks as the second leading cause of global cancer-related deaths and is characterized by a poor prognosis. Eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) have been ...

    Authors: Jie Zhao, Qiang Huo, Ji Zhang, Kexiang Sun, Jinhui Guo, Feng Cheng, Xiaoge Hu and Qiuran Xu
    Citation: Biology Direct 2024 19:53
    Content type: Research Published on:

  28. Esophageal carcinoma (EC) and gastric cardiac adenocarcinoma (GCA) have high incidence rates in the Chaoshan region of South China. Multifocal esophageal and cardiac cancer (MECC) is commonly observed in this ...

    Authors: Xi Liu, Lijun Cai, Juan Ji, Dongping Tian, Yi Guo, Shaobin Chen, Meng Zhao and Min Su
    Citation: Biology Direct 2024 19:51
    Content type: Research Published on:

  29. Prostate cancer (PCa) is the second leading cause of tumor-related mortality in men. Metastasis from advanced tumors is the primary cause of death among patients. Identifying novel and effective biomarkers is ...

    Authors: YaXuan Wang, Bo Ji, Lu Zhang, Jinfeng Wang, JiaXin He, BeiChen Ding and MingHua Ren
    Citation: Biology Direct 2024 19:50
    Content type: Research Published on:

  30. Most patients with acute myeloid leukemia (AML) eventually develop drug resistance, leading to a poor prognosis. Dysregulated long gene non coding RNAs (lincRNAs) have been implicated in chemoresistance in AML...

    Authors: Yue Liu, Xiao-ya Zhu, Li-li Liao, Zhan-hui Zhang, Tao-sheng Huang, Ling Zhang, Xi-wen Jiang and Yi Ma
    Citation: Biology Direct 2024 19:49
    Content type: Research Published on:

  31. Prior research has highlighted the involvement of a transcriptional complex comprising C-terminal binding protein 2 (CtBP2), histone acetyltransferase p300, and nuclear factor kappa B (NF-κB) in the transactiv...

    Authors: Fan Li, Wenqing Yan, Weihua Dong, Zhiping Chen and Zhi Chen
    Citation: Biology Direct 2024 19:48
    Content type: Research Published on:

  32. Long noncoding RNAs (lncRNAs) are implicated in the initiation and progression of diffuse large B-cell lymphoma (DLBCL). Small nucleolar RNA host gene 20 (SNHG20) has been recognized as a critical lncRNA in mu...

    Authors: Chaoyu Wang, Wen Fu, Youju Zhang, Xiaoge Hu, Qiuran Xu and Xiangmin Tong
    Citation: Biology Direct 2024 19:47
    Content type: Research Published on:

  34. Glioma is a common tumor that occurs in the brain and spinal cord. Hypoxia is a crucial feature of the tumor microenvironment. Tumor-associated macrophages/microglia play a crucial role in the advancement of g...

    Authors: Jinchao Si, Jingya Guo, Xu Zhang, Wei Li, Shen Zhang, Shuyu Shang and Quanwu Zhang
    Citation: Biology Direct 2024 19:45
    Content type: Research Published on:

  35. The molecular mechanisms of osteosarcoma (OS) are complex. In this study, we focused on the functions of melanoma cell adhesion molecule (MCAM), methyltransferase 3 (METTL3) and insulin like growth factor 2 mR...

    Authors: Dongjian Song, Qi Wang, Zechen Yan, Meng Su, Hui Zhang, Longyan Shi, Yingzhong Fan, Qian Zhang, Heying Yang, Da Zhang and Qiuliang Liu
    Citation: Biology Direct 2024 19:44
    Content type: Research Published on:

  37. Triple-negative breast cancer (TNBC) is more aggressive and has a higher metastasis rate compared with other subtypes of breast cancer. Due to the lack of drug-targetable receptors, chemotherapy is now the onl...

    Authors: Yuxiang Lin, Yan Li, Xiaobin Chen, Xuan Jin, Meichen Jiang, Han Xiao, Lili Chen, Minyan Chen, Wenzhe Zhang, Hanxi Chen, Qian Nie, Rongrong Guo, Wenhui Guo, Fangmeng Fu and Chuan Wang
    Citation: Biology Direct 2024 19:42
    Content type: Research Published on:

  38. The enzymes performing protein post-translational modifications (PTMs) form a critical post-translational regulatory circuitry that orchestrates literally all cellular processes in the organism. In particular,...

    Authors: Alexandra Daks, Sergey Parfenyev, Oleg Shuvalov, Olga Fedorova, Alexander Nazarov, Gerry Melino and Nickolai A. Barlev
    Citation: Biology Direct 2024 19:41
    Content type: Review Published on:

  40. The presence of mesenchymal stem cells has been confirmed in some solid tumors where they serve as important components of the tumor microenvironment; however, their role in cancer has not been fully elucidate...

    Authors: Xiaoyan Gao, He Ren, Zhengrong Zhang, Shuai Cao, Bo Zhang, Qiang Sun, Gerry Melino and Hongyan Huang
    Citation: Biology Direct 2024 19:39
    Content type: Research Published on:

  41. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of RCC with high rates of metastasis. Targeted therapies such as tyrosine kinase and checkpoint inhibitors have improved treatment success, bu...

    Authors: Konrad Grützmann, Karsten Salomo, Alexander Krüger, Andrea Lohse-Fischer, Kati Erdmann, Michael Seifert, Gustavo Baretton, Daniela Aust, Doreen William, Evelin Schröck, Christian Thomas and Susanne Füssel
    Citation: Biology Direct 2024 19:38
    Content type: Research Published on:

  43. Epidermal growth factor receptor (EGFR)-targeted therapy is an important treatment for RAS wild-type metastatic colorectal cancer (mCRC), but the resistance mechanism remains unclear. Here, the differential ex...

    Authors: Yiting Geng, Xiao Zheng, Dachuan Zhang, Shanshan Wei, Jun Feng, Wei Wang, Luo Zhang, Changping Wu and Wenwei Hu
    Citation: Biology Direct 2024 19:36
    Content type: Research Published on:

  44. Ubiquitin-conjugating enzyme E2 N (UBE2N) is recognized in the progression of some cancers; however, little research has been conducted to describe its role in prostate cancer. The purpose of this paper is to ...

    Authors: Bo Yang, Weihua Chen, Tianyi Tao, Jun Zhang, Dehui Kong, Jidong Hao, Chao Yu, Guoqiang Liao and Hua Gong
    Citation: Biology Direct 2024 19:35
    Content type: Research Published on:

  45. LncRNA PCED1B-AS1 is abnormally expressed in multiple cancers and has been confirmed as an oncogene. Our study aimed to investigate the regulatory mechanism of lncRNA PCED1B-AS1 in gastric cancer.

    Authors: Jia Cao, Yicheng Yang, Bensong Duan, Haibin Zhang, Qinwei Xu, Junyi Han and Bing Lu
    Citation: Biology Direct 2024 19:34
    Content type: Research Published on:

  46. The Advanced Plant Experiment-04 - Epigenetic Expression (APEX-04-EpEx) experiment onboard the International Space Station examined the spaceflight-altered cytosine methylation in two genetic lines of Arabidopsis...

    Authors: Mingqi Zhou, Alberto Riva, Marie-Pierre L. Gauthier, Michael P. Kladde, Robert J. Ferl and Anna-Lisa Paul
    Citation: Biology Direct 2024 19:33
    Content type: Research Published on:

  47. Doxorubicin (Dox) is associated with various liver injuries, limiting its clinical utility. This study investigates whether NSUN2 participates in Dox-induced liver injury and the associated molecular mechanism.

    Authors: Yingying Huang, Xiao Li, Lin Wei, Shinan Ma, Liming Ma, Yuxin Zan, Xiju He, Yijun Tang and Yan Ding
    Citation: Biology Direct 2024 19:32
    Content type: Research Published on:

  48. Deubiquitinating enzymes (DUBs) cleave ubiquitin on substrate molecules to maintain protein stability. DUBs reportedly participate in the tumorigenesis and tumour progression of hepatocellular carcinoma (HCC)....

    Authors: Yingnan Yang, Siying Jia, Ning Zhu, Xuelian Xiao, Ying Ma, Kangsheng Tu, Yong Guo and Qiuran Xu
    Citation: Biology Direct 2024 19:31
    Content type: Research Published on:

  49. Large bone defects pose a clinical treatment challenge; inhibiting transferrin receptor 2 (TfR2), which is involved in iron metabolism, can promote osteogenesis. Iron-based metal-organic frameworks (MOF-Fe) pa...

    Authors: Yaxin Xue, Wei Xu, Danyang Zhao, Zijing Du, Hao Jiang, Hao Lv, Dong Zhang, Zhencheng Yu, Yi Cao and Dong Han
    Citation: Biology Direct 2024 19:30
    Content type: Research Published on:

  50. Oocyte quality is critical for the mammalian reproduction due to its necessity on fertilization and early development. During aging, the declined oocytes showing with organelle dysfunction and oxidative stress...

    Authors: Lin-Lin Hu, Mei-Hua Liao, Ya-Xi Liu, Chun-Hua Xing, Lan-Lan Nong, Feng-Lian Yang and Shao-Chen Sun
    Citation: Biology Direct 2024 19:29
    Content type: Research Published on:
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Biology Direct

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