Structural and Molecular Biology

Section edited by Jeffrey Skolnick and Nick Grishin

The Structural and Molecular Biology section welcomes articles investigating both the structure of biological macromolecules and the molecular basis of biological activity. Specific areas of interest include, but are not limited to, the structure and function of proteins, nucleic acids and macormolecules in addition to studies on all aspects of DNA and RNA function and processing in a cellular context.

  1. Research

    Thermodynamic and kinetic stability of the Josephin Domain closed arrangement: evidences from replica exchange molecular dynamics

    Molecular phenomena driving pathological aggregation in neurodegenerative diseases are not completely understood yet. Peculiar is the case of Spinocerebellar Ataxia 3 (SCA3) where the conformational properties...

    Gianvito Grasso, Jack A. Tuszynski, Umberto Morbiducci, Ginevra Licandro, Andrea Danani and Marco A. Deriu

    Biology Direct 2017 12:2

    Published on: 19 January 2017

  2. Hypothesis

    The role of the backbone torsion in protein folding

    The set of forces and sequence of events that govern the transition from an unfolded polypeptide chain to a functional protein with correct spatial structure remain incompletely known, despite the importance o...

    Irina Sorokina and Arcady Mushegian

    Biology Direct 2016 11:64

    Published on: 1 December 2016

  3. Research

    Cpf1 nucleases demonstrate robust activity to induce DNA modification by exploiting homology directed repair pathways in mammalian cells

    Cpf1 nucleases have recently been repurposed for site-specific genome modification. Two members of the Cpf1 family, the AsCpf1 from Acidaminococcus sp. and the LbCpf1 from Lachnospiraceae bacterium were shown to ...

    Eszter Tóth, Nóra Weinhardt, Petra Bencsura, Krisztina Huszár, Péter I. Kulcsár, András Tálas, Elfrieda Fodor and Ervin Welker

    Biology Direct 2016 11:46

    Published on: 14 September 2016

  4. Research

    Biochemical and biophysical characterization of cell-free synthesized Rift Valley fever virus nucleoprotein capsids enables in vitro screening to identify novel antivirals

    Viral capsid assembly involves the oligomerization of the capsid nucleoprotein (NP), which is an essential step in viral replication and may represent a potential antiviral target. An in vitro transcription-tr...

    Sean Broce, Lisa Hensley, Tomoharu Sato, Joshua Lehrer-Graiwer, Christian Essrich, Katie J. Edwards, Jacqueline Pajda, Christopher J. Davis, Rami Bhadresh, Clarence R. Hurt, Beverly Freeman, Vishwanath R. Lingappa, Colm A. Kelleher and Marcela V. Karpuj

    Biology Direct 2016 11:25

    Published on: 14 May 2016

  5. Research

    The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells

    The family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion of m...

    Miguel Chaves-Ferreira, Gerald Krenn, Florence Vasseur, Aleksandr Barinov, Pedro Gonçalves, Orly Azogui, Ana Cumano, Zhi Li, Sandra Pellegrini, Benedita Rocha and Diego Laderach

    Biology Direct 2016 11:21

    Published on: 29 April 2016

  6. Discovery notes

    Endothelial function is impaired in conduit arteries of pannexin1 knockout mice

    Pannexin1 is ubiquitously expressed in vertebrate tissues, but the role it plays in vascular tone regulation remains unclear. We found that Pannexin1 expression level is much higher in the endothelium relative...

    Dina Gaynullina, Olga S Tarasova, Oxana O Kiryukhina, Valery I Shestopalov and Yuri Panchin

    Biology Direct 2014 9:8

    Published on: 17 May 2014