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Structural and Molecular Biology

Section edited by Jeffrey Skolnick and Nick Grishin

The Structural and Molecular Biology section welcomes articles investigating both the structure of biological macromolecules and the molecular basis of biological activity. Specific areas of interest include, but are not limited to, the structure and function of proteins, nucleic acids and macormolecules in addition to studies on all aspects of DNA and RNA function and processing in a cellular context.

  1. Content type: Research

    A basic tenet of protein science is that all information about the spatial structure of proteins is present in their sequences. Nonetheless, many proteins fail to attain native structure upon experimental dena...

    Authors: Irina Sorokina and Arcady Mushegian

    Citation: Biology Direct 2017 12:14

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  2. Content type: Research

    Molecular phenomena driving pathological aggregation in neurodegenerative diseases are not completely understood yet. Peculiar is the case of Spinocerebellar Ataxia 3 (SCA3) where the conformational properties...

    Authors: Gianvito Grasso, Jack A. Tuszynski, Umberto Morbiducci, Ginevra Licandro, Andrea Danani and Marco A. Deriu

    Citation: Biology Direct 2017 12:2

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  3. Content type: Hypothesis

    The set of forces and sequence of events that govern the transition from an unfolded polypeptide chain to a functional protein with correct spatial structure remain incompletely known, despite the importance o...

    Authors: Irina Sorokina and Arcady Mushegian

    Citation: Biology Direct 2016 11:64

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  4. Content type: Research

    Cpf1 nucleases have recently been repurposed for site-specific genome modification. Two members of the Cpf1 family, the AsCpf1 from Acidaminococcus sp. and the LbCpf1 from Lachnospiraceae bacterium were shown to ...

    Authors: Eszter Tóth, Nóra Weinhardt, Petra Bencsura, Krisztina Huszár, Péter I. Kulcsár, András Tálas, Elfrieda Fodor and Ervin Welker

    Citation: Biology Direct 2016 11:46

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  5. Content type: Research

    Viral capsid assembly involves the oligomerization of the capsid nucleoprotein (NP), which is an essential step in viral replication and may represent a potential antiviral target. An in vitro transcription-tr...

    Authors: Sean Broce, Lisa Hensley, Tomoharu Sato, Joshua Lehrer-Graiwer, Christian Essrich, Katie J. Edwards, Jacqueline Pajda, Christopher J. Davis, Rami Bhadresh, Clarence R. Hurt, Beverly Freeman, Vishwanath R. Lingappa, Colm A. Kelleher and Marcela V. Karpuj

    Citation: Biology Direct 2016 11:25

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  6. Content type: Research

    The family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion of m...

    Authors: Miguel Chaves-Ferreira, Gerald Krenn, Florence Vasseur, Aleksandr Barinov, Pedro Gonçalves, Orly Azogui, Ana Cumano, Zhi Li, Sandra Pellegrini, Benedita Rocha and Diego Laderach

    Citation: Biology Direct 2016 11:21

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  7. Content type: Discovery notes

    Microbial rhodopsins and G-protein coupled receptors (GPCRs, which include animal rhodopsins) are two distinct (super) families of heptahelical (7TM) membrane proteins that share obvious structural similaritie...

    Authors: Daria N. Shalaeva, Michael Y. Galperin and Armen Y. Mulkidjanian

    Citation: Biology Direct 2015 10:63

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  8. Content type: Discovery notes

    Pannexin1 is ubiquitously expressed in vertebrate tissues, but the role it plays in vascular tone regulation remains unclear. We found that Pannexin1 expression level is much higher in the endothelium relative...

    Authors: Dina Gaynullina, Olga S Tarasova, Oxana O Kiryukhina, Valery I Shestopalov and Yuri Panchin

    Citation: Biology Direct 2014 9:8

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