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  1. All archaeal and many bacterial genomes contain Clustered Regularly Interspaced Short Palindrome Repeats (CRISPR) and variable arrays of the CRISPR-associated (cas) genes that have been previously implicated in a...

    Authors: Kira S Makarova, Nick V Grishin, Svetlana A Shabalina, Yuri I Wolf and Eugene V Koonin

    Citation: Biology Direct 2006 1:7

    Content type: Research

    Published on:

  2. Oncolytic viruses that specifically target tumor cells are promising anti-cancer therapeutic agents. The interaction between an oncolytic virus and tumor cells is amenable to mathematical modeling using adapta...

    Authors: Artem S Novozhilov, Faina S Berezovskaya, Eugene V Koonin and Georgy P Karev

    Citation: Biology Direct 2006 1:6

    Content type: Research

    Published on:

  3. For the purposes of phylogenetic inference from molecular data sets many different methods are currently offered as alternatives for researchers in phylogenetic systematics. The vast majority of these methods ...

    Authors: Srdan V Stankov

    Citation: Biology Direct 2006 1:5

    Content type: Research

    Published on:

  4. The mutation spectra of the TP53 gene and other tumor suppressors contain multiple hotspots, i.e., sites of non-random, frequent mutation in tumors and/or the germline. The origin of the hotspots remains unclear,...

    Authors: Galina V Glazko, Vladimir N Babenko, Eugene V Koonin and Igor B Rogozin

    Citation: Biology Direct 2006 1:4

    Content type: Research

    Published on:

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