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  1. The uc.291 transcript controls keratinocytes differentiation by physical interaction with ACTL6A and subsequent induction of transcription of the genes belonging to the epidermal differentiation complex (EDC)....

    Authors: Mara Mancini, Simone Sergio, Angela Cappello, Timea Farkas, Francesca Bernassola, Claudia Scarponi, Cristina Albanesi, Gerry Melino and Eleonora Candi
    Citation: Biology Direct 2023 18:82
  2. The human bone marrow mesenchymal stem cells (hBMSCs) undergo intense osteogenic differentiation, a crucial bone formation mechanism. Evidence from prior studies suggested an association between long noncoding...

    Authors: Zhaoyi Mai, Jingpeng Liu, Xiao Jiang, Wenli Gu, Wei Wang, Simin Li, Gerhard Schmalz, Hui Xiao and Jianjiang Zhao
    Citation: Biology Direct 2023 18:81
  3. Regulator of chromosome condensation 2 (RCC2) was a telophase disk-binding protein on mitosis, and functions as an oncogene in many human cancers. However, its role on prostate cancer (PCa) was unknown. The go...

    Authors: Shenghan Wang, Zhentao Lei, Wei Liu, Jie Xiong, Yuqiang Shi, Lin Yang, Qiang Gao, Kai Le and Bao Zhang
    Citation: Biology Direct 2023 18:80
  4. MicroRNAs (miRNAs) play critical roles in cancer initiation and progression, which were critical components to maintain the dynamic balance of competing endogenous RNA (ceRNA) networks. Somatic copy number alt...

    Authors: Renjie Dou, Shaobo Kang, Huan Yang, Wanmei Zhang, Yijing Zhang, Yuanyuan Liu, Yanyan Ping and Bo Pang
    Citation: Biology Direct 2023 18:79
  5. Regulator of G protein signaling 5 (RGS5), as a negative regulator of G protein-coupled receptor (GPCR) signaling, is highly expressed in arterial VSMCs and pericytes, which is involved in VSMC phenotypic hete...

    Authors: Peng Kong, Xu Wang, Ya-Kun Gao, Dan-Dan Zhang, Xiao-Fu Huang, Yu Song, Wen-Di Zhang, Rui-Juan Guo, Han Li and Mei Han
    Citation: Biology Direct 2023 18:78
  6. Pancreatic cancer is a malignancy with high mortality. Once diagnosed, effective treatment strategies are limited and the five-year survival is extremely poor. Recent studies have shown that zinc finger protei...

    Authors: Qifeng Xiao, Zhongmin Lan, Shuisheng Zhang, Hu Ren, Shunda Wang, Peng Wang, Lin Feng, Dan Li, Chengfeng Wang, Xiaofeng Bai and Jianwei Zhang
    Citation: Biology Direct 2023 18:77
  7. Extracellular vesicles (EVs) derived from various cell sources exert cardioprotective effects during cardiac ischemic injury. Our previous study confirmed that EVs derived from ischemic-reperfusion injured hea...

    Authors: Xuan Liu, Shanshan Shi, Xuedi Geng, Enhao Wang, Qingshu Meng, Mimi Li, Fang Lin, Xiaoxue Ma, Wei Han and Xiaohui Zhou
    Citation: Biology Direct 2023 18:76
  8. Ligamentum flavum (LF) hypertrophy is the main cause of lumbar spinal canal stenosis (LSCS). Previous studies have shown that LF hypertrophy tissue exhibits abnormal lipid accumulation, but the regulatory mech...

    Authors: Yanlin Cao, Jianjun Li, Sujun Qiu, Songjia Ni and Yang Duan
    Citation: Biology Direct 2023 18:75
  9. Cancer stemness and osteosarcoma (OS) malignant progression are closely associated. However, the molecular mechanisms underlying this association have not been fully demonstrated. Long noncoding RNAs (lncRNAs)...

    Authors: Zhining Yang, Zhaoyong Liu, Weiqing Lu, Huancheng Guo, Jianzhou Chen and Ying Zhang
    Citation: Biology Direct 2023 18:74
  10. Head and neck squamous cell carcinoma (HNSCC) is characterized by high proliferation and limited differentiation. The altered expression of the p53 family members, and specifically of p63, represents a pivotal...

    Authors: Angela Cappello, Giulia Tosetti, Artem Smirnov, Carlo Ganini, Xue Yang, Yufang Shi, Ying Wang, Gerry Melino, Francesca Bernassola and Eleonora Candi
    Citation: Biology Direct 2023 18:73
  11. Malignant melanoma is a highly heterogeneous skin cancer with the highest mortality rate among dermatological cancers. Catenins form functional networks in the nucleus to regulate gene expression and determine...

    Authors: Yi-dou Hu, Ke Wu, Yuan-jie Liu, Qian Zhang, Hui Shen, Jin Ji, Dong Fang and Song-yang Xi
    Citation: Biology Direct 2023 18:72
  12. Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor i...

    Authors: Peng Liu, Liwei Zhao, Guido Kroemer and Oliver Kepp
    Citation: Biology Direct 2023 18:71
  13. The study aimed to identify transcripts of specific ion channels in rat ventricular cardiomyocytes and determine their potential role in the regulation of ionic currents in response to mechanical stimulation. ...

    Authors: Andre G. Kamkin, Olga V. Kamkina, Viktor E. Kazansky, Vadim M. Mitrokhin, Andrey Bilichenko, Elizaveta A. Nasedkina, Stanislav A. Shileiko, Anastasia S. Rodina, Alexandra D. Zolotareva, Valentin I. Zolotarev, Pavel V. Sutyagin and Mitko I. Mladenov
    Citation: Biology Direct 2023 18:70
  14. Bcl-B is a poorly understood protein of the Bcl-2 family that is highly expressed in many healthy tissues and tumor types. Bcl-B is considered an antiapoptotic protein, but many reports have revealed its contr...

    Authors: N. V. Pervushin, G. S. Kopeina and B. Zhivotovsky
    Citation: Biology Direct 2023 18:69
  15. Nuclear respiratory factor 1 (NRF1) is a transcription factor that participates in several kinds of tumor, but its role in hepatocellular carcinoma (HCC) remains elusive. This study aims to explore the role of...

    Authors: Ran Liu, Chuanzheng Yin, Peng Zhao, Bing Guo, Wenbo Ke, Xichuan Zheng, Dawei Xie, Yaofeng Wang, Gengqiao Wang, Yinzhao Jia, Yang Gao, Wenjun Hu, Gang Logan Liu and Zifang Song
    Citation: Biology Direct 2023 18:67
  16. The social impact of glaucoma is worth of note: primary open-angle glaucoma (POAG) is one of the leading causes of irreversible blindness worldwide, affecting some 68.56 million people with overall prevalence ...

    Authors: Damiana Scuteri, Giulio Pocobelli, Yoichi Sakurada, Rossella Russo, Paolo Tonin, Pierluigi Nicotera, Giacinto Bagetta, Maria Tiziana Corasaniti and Carlo Nucci
    Citation: Biology Direct 2023 18:66
  17. Kruppel-like factor 13 (KLF13) is a transcription factor and plays an important role in carcinogenesis. However, the significance of KLF13 in thyroid carcinoma (THCA) is underdetermined. In this study, we aime...

    Authors: Yang Liu, Yixuan Song, Yuqin He, Ziren Kong, Han Li, Yiming Zhu and Shaoyan Liu
    Citation: Biology Direct 2023 18:65
  18. Despite improvements in prognosis due to advances in treatment, including surgery, genetic screening, and molecular targeted therapy, the outcomes of ovarian cancer (OC) remain unsatisfactory. Internal mRNA mo...

    Authors: Lijuan Gan, Shengchao Zhao, Yang Gao, Yuwen Qi, Min Su, Anjin Wang and Hongbing Cai
    Citation: Biology Direct 2023 18:64
  19. Anthracyclines including doxorubicin are essential components of many cancer chemotherapy regimens, but their cardiotoxicity severely limits their use. New strategies for treating anthracycline-induced cardiot...

    Authors: Xuechun Chen, Changtong Liu, Hong Zhao, Yigang Zhong, Yizhou Xu and Yi Wang
    Citation: Biology Direct 2023 18:63
  20. Authors: Salwa Soussi, Lesia Savchenko, Davide Rovina, Jason S. Iacovoni, Andrea Gottinger, Maxime Vialettes, Josè-Manuel Pioner, Andrea Farini, Sara Mallia, Martina Rabino, Giulio Pompilio, Angelo Parini, Olivier Lairez, Aoife Gowran and Nathalie Pizzinat
    Citation: Biology Direct 2023 18:62

    The original article was published in Biology Direct 2023 18:41

  21. Severe traumatic brain injury (TBI) is one of the most dramatic events in pediatric age and, despite advanced neuro-intensive care, the survival rate of these patients remains low. Children suffering from seve...

    Authors: Antonio Gatto, Lavinia Capossela, Giorgio Conti, Gemma Eftimiadi, Serena Ferretti, Luigi Manni, Antonietta Curatola, Benedetta Graglia, Lorenzo Di Sarno, Maria Lucia Calcagni, Daniela Di Giuda, Stefano Cecere, Domenico Marco Romeo, Marzia Soligo, Enzo Picconi, Marco Piastra…
    Citation: Biology Direct 2023 18:61
  22. Peroxisomes play a central role in tuning metabolic and signaling programs in a tissue- and cell-type-specific manner. However, the mechanisms by which the status of peroxisomes is communicated and integrated ...

    Authors: Akihiro Yamashita, Olesia Ignatenko, Mai Nguyen, Raphaëlle Lambert, Kathleen Watt, Caroline Daneault, Isabelle Robillard-Frayne, Ivan Topisirovic, Christine Des Rosiers and Heidi M. McBride
    Citation: Biology Direct 2023 18:60
  23. The thymus is required for T cell development and the formation of the adaptive immunity. Stromal cells, which include thymic epithelial cells (TECs) and mesenchymal stromal cells (MSCs), are essential for thy...

    Authors: Xiao Su, Xiaolei Li, Shiqing Wang, Xiaotong Xue, Rui Liu, Xiaojing Bai, Pixia Gong, Chao Feng, Lijuan Cao, Tingting Wang, Yayun Ding, Junjie Jiang, Yongjing Chen, Yufang Shi and Changshun Shao
    Citation: Biology Direct 2023 18:59
  24. Spinal muscular atrophy (SMA) is a rare autosomal-recessive neurodegenerative disorder caused by mutations in survival motor neuron 1 (SMN1) gene, and consequent loss of function of SMN protein, which results in ...

    Authors: M. Garofalo, S. Bonanno, S. Marcuzzo, C. Pandini, E. Scarian, F. Dragoni, R. Di Gerlando, M. Bordoni, S. Parravicini, C. Gellera, R. Masson, C. Dosi, R. Zanin, O. Pansarasa, C. Cereda, A. Berardinelli…
    Citation: Biology Direct 2023 18:57
  25. Tumor-associated macrophages (TAMs) are an important subset of innate immune cells in the tumor microenvironment, and they are pivotal regulators of tumor-promoting inflammation and tumor progression. Evidence...

    Authors: Yandong Zhang, Shu Ma, Tie Li, Yu Tian, Huangao Zhou, Hongsheng Wang and Lan Huang
    Citation: Biology Direct 2023 18:56

    The Correction to this article has been published in Biology Direct 2023 18:83

  26. Perilipin 5 (Plin5) is well known to maintain the stability of intracellular lipid droplets (LDs) and regulate fatty acid metabolism in oxidative tissues. It is highly expressed in the heart, but its roles hav...

    Authors: Lele Jian, Xing Gao, Chao Wang, Xiao Sun, Yuqiao Xu, Ruili Han, Yuying Wang, Shenhui Xu, Lan Ding, Jingjun Zhou, Yu Gu, Yuanlin Zhao, Ying Yang, Yuan Yuan, Jing Ye and Lijun Zhang
    Citation: Biology Direct 2023 18:54
  27. Hepatocellular carcinoma (HCC) is one of the most common and challenging cancers in the world. N6-methyladenosine (m6A) modification and long non-coding RNAs (lncRNAs) play critical roles in the progression of HC...

    Authors: Runkun Liu, Guozhi Yin, Hang Tuo, Yixian Guo, Yifeng Zhu, Lei Zhang, Wei Yang, Qingguang Liu and Yufeng Wang
    Citation: Biology Direct 2023 18:53
  28. Helicobacter pylori (H.pylori, HP) is one of the main causes of gastric cancer (GC). CircRNAs have been reported to play a crucial role in developing many types of cancer. However, the role of circRNAs in the dev...

    Authors: Yun Liu, Jia Cao, Qi Yang, Linqi Zhu, Wenjun Zhao, Xiuping Wang, Jun Yao, Yong Zhou and Shihe Shao
    Citation: Biology Direct 2023 18:51
  29. The response rate to obeticholic acid (OCA), a potential therapeutic agent for non-alcoholic fatty liver disease, is limited. This study demonstrated that upregulation of the alternative bile acid synthesis pa...

    Authors: Seung Min Lee, Dae Won Jun, Eileen Laurel Yoon, Ju Hee Oh, Yoon Jin Roh, Eun Jeoung Lee, Ji-Hee Shin, Young-Do Nam and Hyun Sung Kim
    Citation: Biology Direct 2023 18:50
  30. The light-harvesting antennae of photosystem (PS) I and PSII are pigment-protein complexes responsible of the initial steps of sunlight conversion into chemical energy. In natural environments plants are const...

    Authors: Edoardo Andrea Cutolo, Roberto Caferri, Zeno Guardini, Luca Dall’Osto and Roberto Bassi
    Citation: Biology Direct 2023 18:49
  31. Circular RNAs (circRNAs) have been shown to play diverse biological functions in the progression of multiple diseases. However, the impacts of circRNAs on breast cancer (BC) progression remains unclear. Theref...

    Authors: Juan Li, Xiangjun Dong, Xue Kong, Yafen Wang, Yanru Li, Yao Tong, Wenjing Zhao, Weili Duan, Peilong Li, Yanqun Wang and Chuanxin Wang
    Citation: Biology Direct 2023 18:48
  32. C-to-U RNA editing in plants is believed to confer its evolutionary adaptiveness by reversing unfavorable DNA mutations. This “restorative hypothesis” has not yet been tested genome-wide. In contrast, A-to-I R...

    Authors: Yuange Duan, Ye Xu, Fan Song, Li Tian, Wanzhi Cai and Hu Li
    Citation: Biology Direct 2023 18:47
  33. It is generally accepted that most evolutionary transformations at the phenotype level are associated either with rearrangements of genomic regulatory elements, which control the activity of gene networks, or ...

    Authors: Vassily A. Lyubetsky, Lev I. Rubanov, Maria B. Tereshina, Anastasiya S. Ivanova, Karina R. Araslanova, Leonid A. Uroshlev, Galina I. Goremykina, Jian-Rong Yang, Vladimir G. Kanovei, Oleg A. Zverkov, Alexander D. Shitikov, Daria D. Korotkova and Andrey G. Zaraisky
    Citation: Biology Direct 2023 18:45
  34. Patients with triple-negative breast cancer (TNBC) tend to develop visceral metastasis within five years, making them the most challenging BC patients to treat. The MAP7 protein family is a group of microtubul...

    Authors: Wen-Hung Kuo, Pei-Yi Chu, Chen-Chi Wang, Ping-Shen Huang and Shih-Hsuan Chan
    Citation: Biology Direct 2023 18:44
  35. Antipsychotic drugs are the mainstay of treatment for schizophrenia and provide adjunct therapies for other prevalent psychiatric conditions, including bipolar disorder and major depressive disorder. However, ...

    Authors: Rachel E. Hardy, Injae Chung, Yizhou Yu, Samantha H. Y. Loh, Nobuhiro Morone, Clement Soleilhavoup, Marco Travaglio, Riccardo Serreli, Lia Panman, Kelvin Cain, Judy Hirst, Luis M. Martins, Marion MacFarlane and Kenneth R. Pryde
    Citation: Biology Direct 2023 18:43
  36. Volumetric Muscle Loss (VML), resulting from severe trauma or surgical ablation, is a pathological condition preventing myofibers regeneration, since skeletal muscle owns the remarkable ability to restore tiss...

    Authors: Francesca De Paolis, Stefano Testa, Gabriele Guarnaccia, Alessio Reggio, Ersilia Fornetti, Felice Cicciarelli, Rebecca Deodati, Sergio Bernardini, Daniele Peluso, Jacopo Baldi, Roberto Biagini, Flavia Cobianchi Bellisari, Antonio Izzo, Ferruccio Sgalambro, Francesco Arrigoni, Francesco Rizzo…
    Citation: Biology Direct 2023 18:42
  37. Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy caused by mutations in the dystrophin gene. We characterized which isoforms of dystrophin were expressed by human induced pluripotent st...

    Authors: Salwa Soussi, Lesia Savchenko, Davide Rovina, Jason S. Iacovoni, Andrea Gottinger, Maxime Vialettes, Josè-Manuel Pioner, Andrea Farini, Sara Mallia, Martina Rabino, Giulio Pompilio, Angelo Parini, Olivier Lairez, Aoife Gowran and Nathalie Pizzinat
    Citation: Biology Direct 2023 18:41

    The Correction to this article has been published in Biology Direct 2023 18:62

  38. Natural ageing of organisms and corresponding age-related diseases result mainly from stem cell ageing and “inflammaging”. Mesenchymal stem cells (MSCs) exhibit very high immune-regulating capacity and are pro...

    Authors: Xue Yang, Ying Wang, Valentina Rovella, Eleonora Candi, Wei Jia, Francesca Bernassola, Pierluigi Bove, Mauro Piacentini, Manuel Scimeca, Giuseppe Sica, Giuseppe Tisone, Alessandro Mauriello, Lixin Wei, Gerry Melino and Yufang Shi
    Citation: Biology Direct 2023 18:40
  39. Previously, we identified an oncogenic splicing variant of DOCK5 in head and neck squamous cell carcinoma (HNSCC); however, the mechanism for the generation of this specific DOCK5 variant remains unknown. This...

    Authors: Chao Liu, Guo Li, Siyuan Zheng, Li She, Shanhong Lu, Yunyun Wang, Donghai Huang, Xin Zhang, Lunquan Sun, Yong Liu and Yuanzheng Qiu
    Citation: Biology Direct 2023 18:39
  40. Prostate cancer remains one of the deadliest neoplasms in developed countries. Identification of new molecular markers that predict the onset and progression of the disease could improve its clinical managemen...

    Authors: Matthieu Le Hars, Luis Jaime Castro-Vega, Fatemeh Rajabi, David Tabatadze, Martha Romero, Marina Pinskaya and Irina Groisman
    Citation: Biology Direct 2023 18:38
  41. Intervertebral disc degeneration (IDD) naturally occurs during the aging process. Its occurrence is closely related to chronic inflammation; however, the causal relationship between them is controversial. This...

    Authors: Xingguo Li, Jun Zhang, Bing Wang, Chao Chen, Enyu Zhang, Zhengpin Lv, Qicong He, Yaoquan Hu, Xuenan Wang and Fan Zhang
    Citation: Biology Direct 2023 18:37
  42. LncRNA PSMA3-AS1 functions as an oncogene in several cancers, including ovarian cancer, lung cancer, and colorectal cancer. However, its role in gastric cancer (GC) progression remains unclear. In this study, ...

    Authors: Liang Kan, Meiqi Yang and Huijing Zhang
    Citation: Biology Direct 2023 18:36
  43. Bicuspid aortic valve (BAV) is the most prevalent congenital valvular heart defect, and around 50% of severe isolated calcific aortic valve disease (CAVD) cases are associated with BAV. Although previous studi...

    Authors: Tao Lyu, Yang Liu, Binglin Li, Ran Xu, Jianghong Guo and Dan Zhu
    Citation: Biology Direct 2023 18:35
  44. Tooth development, as one of the major mineralized tissues in the body, require fine-tuning of mineralization micro-environment. The interaction between dental epithelium and mesenchyme plays a decisive role i...

    Authors: MengDan Zhang, Junming Zheng, Siyuan Wu, Hailing Chen and Lusai Xiang
    Citation: Biology Direct 2023 18:34

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