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  1. Osteosarcoma is a diverse and aggressive bone tumor. Driver genes regulating osteosarcoma initiation and progression remains incompletely defined. Zinc finger protein 692 (ZNF692), a kind of Krüppel C2H2 zinc ...

    Authors: Di Zheng, Zhun Wei, Chong Zhang, Wenda Liu, Changtian Gong, Fei Wu and Weichun Guo
    Citation: Biology Direct 2024 19:28
    Content type: Research Published on:

  3. Ischemic stroke is a sudden and acute disease characterized by neuronal death, increment of reactive gliosis (reactive microglia and astrocytes), and a severe inflammatory process. Neuroinflammation is an earl...

    Authors: Mario Villa-González, Marina Rubio, Gerardo Martín-López, Paula R. Mallavibarrena, Laura Vallés-Saiz, Denis Vivien, Francisco Wandosell and Maria José Pérez-Álvarez
    Citation: Biology Direct 2024 19:26
    Content type: Research Published on:

  4. Circular RNAs (circRNAs) are a class of highly multifunctional single-stranded RNAs that play crucial roles in cancer progression, including osteosarcoma (OS). Circ_0002669, generated from the dedicator of cyt...

    Authors: Ying Zhang, Yizhou Zhan, Zhaoyong Liu, Huancheng Guo, Dongchen Liu and Chuangzhen Chen
    Citation: Biology Direct 2024 19:25
    Content type: Research Published on:

  5. Pancreatic cancer stem cells are crucial for tumorigenesis and cancer metastasis. Presently, long non-coding RNAs were found to be associated with Pancreatic Ductal Adenocarcinoma stemness characteristics but ...

    Authors: Zhenchong Li, Zuyi Ma, Shujie Wang, Qian Yan, Hongkai Zhuang, Zixuan Zhou, Chunsheng Liu, Yubin Chen, Mingqian Han, Zelong Wu, Shanzhou Huang, Qi Zhou, Baohua Hou and Chuanzhao Zhang
    Citation: Biology Direct 2024 19:24
    Content type: Research Published on:

  6. This study seeks to investigate the impacts of Lactobacillus reuteri (L. reuteri) on hepatic ischemia-reperfusion (I/R) injury and uncover the mechanisms involved.

    Authors: Leiyi Zhang, Xiaoxiang Gong, Juan Tan, Rongsen Zhang, Mingxia Li, Cong Liu, Chenhao Wu and Xiaojing Li
    Citation: Biology Direct 2024 19:23
    Content type: Research Published on:

  7. Neutral/alkaline invertases (N/AINVs) play a crucial role in plant growth, development, and stress response, by irreversibly hydrolyzing sucrose into glucose and fructose. However, research on cotton in this a...

    Authors: Kaikai Qiao, Qingtao Zeng, Jiaoyan Lv, Lingling Chen, Juxin Hao, Ding Wang, Qifeng Ma and Shuli Fan
    Citation: Biology Direct 2024 19:22
    Content type: Research Published on:

  8. Mammalian enabled (MENA) protein is a member of the enabled/vasodilator stimulated phosphoprotein (Ena/VASP) protein family, which regulates cytoplasmic actin network assembly. It plays a significant role in b...

    Authors: Lifang He, Chuanghong She, Sen Jiang, Zhaochang Qi, Zihao Deng, Likeng Ji, Yukun Cui and Jundong Wu
    Citation: Biology Direct 2024 19:21
    Content type: Research Published on:

  9. CircLRIG1, a newly discovered circRNA, has yet to have its potential function and biological processes reported. This study explored the role of circLRIG1 in the development and progression of bladder carcinoma a...

    Authors: Shiliang Cheng, Chunguang Li, Lu Liu, Xinli Liu, Meng Li, Jinhua Zhuo, Jue Wang, Wen Zheng and Zhongmin Wang
    Citation: Biology Direct 2024 19:20
    Content type: Research Published on:

  10. Esophageal squamous cell carcinoma (ESCC) is the main subtype of esophageal cancer. Current therapeutic effect is far from satisfaction. Hence, identifying susceptible genes and potential targets is necessary ...

    Authors: Zhiwei Chang, Yongxu Jia, Ming Gao, Lijie Song, Weijie Zhang, Ruihua Zhao, Dandan Yu, Xiaolei Liu, Jing Li and Yanru Qin
    Citation: Biology Direct 2024 19:19
    Content type: Research Published on:

  11. STAM Binding Protein Like 1 (STAMBPL1), functions as a deubiquitinase (DUB) and plays a significant role in various types of cancers. However, its effect as a DUB participating in the HCC tumorigenesis and pro...

    Authors: Zhihuai Wang, Yinjie Zhang, Yuhang Shen, Haiyang Zhou, Yuan Gao, Chunfu Zhu and Xihu Qin
    Citation: Biology Direct 2024 19:18
    Content type: Research Published on:

  12. Bladder cancer (BC) is the fourth and tenth most common malignancy in men and women worldwide, respectively. The complexity of the molecular biological mechanism behind BC is a major contributor to the lack of...

    Authors: Du Shen and Shaosan Kang
    Citation: Biology Direct 2024 19:17
    Content type: Research Published on:

    The Correction to this article has been published in Biology Direct 2024 19:27

  13. Cholangiocarcinoma (CCA) is a biliary epithelial malignant tumor with an increasing incidence worldwide. Therefore, further understanding of the molecular mechanisms of CCA progression is required to identify ...

    Authors: Chengshuo Zhang, Yu Wang, Gang Wu, Ning Sun, Han Bai, Xuejian Li, Shuai Han, Haonan Zhou, Ruizhao Qi and Jialin Zhang
    Citation: Biology Direct 2024 19:16
    Content type: Research Published on:

  14. Lenvatinib is an oral small molecule inhibitor approved for treating patients with unresectable hepatocellular carcinoma (HCC) worldwide. Increasing cell sensitivity to lenvatinib would be an effective method ...

    Authors: Yarong Guo, Bao Chai, Hezhao Zhang, Xinhao Chai, Yan Chen, Jun Xu, Liwei Qin and Yuting Chai
    Citation: Biology Direct 2024 19:15
    Content type: Research Published on:

  16. Hepatocellular carcinoma (HCC) is a prevalent malignant tumor that poses a major threat to people’s lives and health. Previous studies have found that multiple deubiquitinating enzymes are involved in the path...

    Authors: Qingsong Wu, Yuanyuan Qiu, Jinhui Guo, Zibo Yuan, Yingnan Yang, Qingwei Zhu, Zhe Zhang, Junwei Guo, Yanfang Wu, Junyu Zhang, Dongsheng Huang, Kangsheng Tu and Xiaoge Hu
    Citation: Biology Direct 2024 19:13
    Content type: Research Published on:

  18. To create a dual-acting vaccine that can fight against tuberculosis, we combined antigenic arabino-mannan analogues with the Ag85B protein. To start the process, we studied the impact of modifying different pa...

    Authors: Roberta Bernardini, Sara Tengattini, Zhihao Li, Luciano Piubelli, Teodora Bavaro, Anamaria Bianca Modolea, Maurizio Mattei, Paola Conti, Stefano Marini, Yongmin Zhang, Loredano Pollegioni, Caterina Temporini and Marco Terreni
    Citation: Biology Direct 2024 19:11
    Content type: Research Published on:

  19. Neuropathic pain is chronic pain and has few effective control strategies. Studies have demonstrated that microRNAs have functions in neuropathic pain. However, no study has been conducted to demonstrate the r...

    Authors: Yuqi Liu, Lijuan Wang, Chengcheng Zhou, Yuan Yuan, Bin Fang, Kaimei Lu, Fangxia Xu, Lianhua Chen and Lina Huang
    Citation: Biology Direct 2024 19:10
    Content type: Research Published on:

  21. Gerontology research on anti-aging interventions with drugs could be an answer to age-related diseases, aiming at closing the gap between lifespan and healthspan. Here, we present two methods for assaying chro...

    Authors: Mohammad Alfatah, Yizhong Zhang, Arshia Naaz, Trishia Yi Ning Cheng and Frank Eisenhaber
    Citation: Biology Direct 2024 19:8
    Content type: Research Published on:

  22. Loss of ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, contributes to malignant progression in multiple cancers including non-small cell lung cancer (NSCLC). In the search for key genes mediating ...

    Authors: Yuanliang Zheng, Lixiang Zhang, Kangliang Zhang, Shenghao Wu, Chichao Wang, Risheng Huang and Hongli Liao
    Citation: Biology Direct 2024 19:7
    Content type: Research Published on:

  23. The outcome of Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) remain dismal despite the development of treatment. Targeted therapy is gaining more and more attention in improving prognosis.

    Authors: Qiao Zhou, Jiamin Zhang, Jingsong Zhang, Simin Liang, Duo Cai, Han Xiao, Yu Zhu, Wenqiong Xiang, Fernando Rodrigues-Lima, Jianxiang Chi, Fabien Guidez and Li Wang
    Citation: Biology Direct 2024 19:6
    Content type: Research Published on:

  24. Individuals whose gender identity differs from the biological sex and the social norms are defined as transgender. Sometimes transgender undergo gender affirming hormone therapy, which lasts for the entire lif...

    Authors: Alessia Tammaro, Gabriele Lori, Andrea Martinelli, Luigia Cancemi, Roberta Tassinari and Francesca Maranghi
    Citation: Biology Direct 2024 19:5
    Content type: Research Published on:

    The Correction to this article has been published in Biology Direct 2024 19:12

  25. Aberrant expression and activation of circular RNAs (circRNAs) are closely associated with various cancers. The role of circ_MAPK9 (hsa_circ_0001566) in cancer progression remains unknown. This study aims to i...

    Authors: Kunyuan Wang, Qianting Lu, Yufeng Luo, Ganxiang Yu, Zhilei Wang, Jiaen Lin, Zhenlin Tan, Yueqiong Lao, Shiming Liu and Hui Yang
    Citation: Biology Direct 2024 19:4
    Content type: Research Published on:

  27. Human Deltex 2 (DTX2) is a ubiquitin E3 ligase that functions as an oncogene and has been shown to participate in many human cancers. However, the role of DTX2 in glioma progression has remained obscure. In th...

    Authors: Ren Li, Yang Chen, Biao Yang, Ziao Li, Peize Li, Yu Chen, Jiayu Li, Jianhang He, Yongqiang Wu, Yanqi Sun, Xiaogang Wang, Xiaolong Guo, Wenju Zhang, Yuanli Zhao and Geng Guo
    Citation: Biology Direct 2024 19:2
    Content type: Research Published on:

  28. Phosphoglycerate kinase 1 (PGK1) is a metabolic enzyme that participates in various biological and pathological processes. Dysregulated PGK1 has been observed in numerous malignancies. However, whether and how...

    Authors: Tian Tian, Yahui Leng, Bingbing Tang, Xiaoxia Dong, Qiulei Ren, Jingyin Liang, Tianhui Liu, Yanni Liu, Wenxiao Feng, Song Liu, Yang Zhou, Hongyan Zhao and Li Shen
    Citation: Biology Direct 2024 19:1
    Content type: Research Published on:

  29. Senescent microglia are a distinct microglial phenotype present in aging brain that have been implicated in the progression of aging and age-related neurodegenerative diseases. However, the specific mechanisms...

    Authors: Anjila Dongol, Xi Chen, Peng Zheng, Zehra Boz Seyhan and Xu-Feng Huang
    Citation: Biology Direct 2023 18:86
    Content type: Research Published on:

  30. Inflammation and nerve injury promote astrocyte activation, which regulates the development and resolution of pain, in the spinal dorsal horn. APOE regulates lipid metabolism and is predominantly expressed in ...

    Authors: Siyi Liu, Shuting Yang, Xuan Zhu, Xiang Li, Xi Zhang, Xiaoqiong Zhou, Hong Cheng, Fu-Quan Huo, Qingxiang Mao and Lingli Liang
    Citation: Biology Direct 2023 18:85
    Content type: Research Published on:

  31. Alström syndrome (ALMS) is a rare autosomal recessive disease that is associated with mutations in ALMS1 gene. The main clinical manifestations of ALMS are retinal dystrophy, obesity, type 2 diabetes mellitus, di...

    Authors: Brais Bea-Mascato, Eduardo Gómez-Castañeda, Yara E. Sánchez-Corrales, Sergi Castellano and Diana Valverde
    Citation: Biology Direct 2023 18:84
    Content type: Research Published on:

  33. The uc.291 transcript controls keratinocytes differentiation by physical interaction with ACTL6A and subsequent induction of transcription of the genes belonging to the epidermal differentiation complex (EDC)....

    Authors: Mara Mancini, Simone Sergio, Angela Cappello, Timea Farkas, Francesca Bernassola, Claudia Scarponi, Cristina Albanesi, Gerry Melino and Eleonora Candi
    Citation: Biology Direct 2023 18:82
    Content type: Research Published on:

  34. The human bone marrow mesenchymal stem cells (hBMSCs) undergo intense osteogenic differentiation, a crucial bone formation mechanism. Evidence from prior studies suggested an association between long noncoding...

    Authors: Zhaoyi Mai, Jingpeng Liu, Xiao Jiang, Wenli Gu, Wei Wang, Simin Li, Gerhard Schmalz, Hui Xiao and Jianjiang Zhao
    Citation: Biology Direct 2023 18:81
    Content type: Research Published on:

  35. Regulator of chromosome condensation 2 (RCC2) was a telophase disk-binding protein on mitosis, and functions as an oncogene in many human cancers. However, its role on prostate cancer (PCa) was unknown. The go...

    Authors: Shenghan Wang, Zhentao Lei, Wei Liu, Jie Xiong, Yuqiang Shi, Lin Yang, Qiang Gao, Kai Le and Bao Zhang
    Citation: Biology Direct 2023 18:80
    Content type: Research Published on:

  36. MicroRNAs (miRNAs) play critical roles in cancer initiation and progression, which were critical components to maintain the dynamic balance of competing endogenous RNA (ceRNA) networks. Somatic copy number alt...

    Authors: Renjie Dou, Shaobo Kang, Huan Yang, Wanmei Zhang, Yijing Zhang, Yuanyuan Liu, Yanyan Ping and Bo Pang
    Citation: Biology Direct 2023 18:79
    Content type: Research Published on:

  37. Regulator of G protein signaling 5 (RGS5), as a negative regulator of G protein-coupled receptor (GPCR) signaling, is highly expressed in arterial VSMCs and pericytes, which is involved in VSMC phenotypic hete...

    Authors: Peng Kong, Xu Wang, Ya-Kun Gao, Dan-Dan Zhang, Xiao-Fu Huang, Yu Song, Wen-Di Zhang, Rui-Juan Guo, Han Li and Mei Han
    Citation: Biology Direct 2023 18:78
    Content type: Research Published on:

  38. Pancreatic cancer is a malignancy with high mortality. Once diagnosed, effective treatment strategies are limited and the five-year survival is extremely poor. Recent studies have shown that zinc finger protei...

    Authors: Qifeng Xiao, Zhongmin Lan, Shuisheng Zhang, Hu Ren, Shunda Wang, Peng Wang, Lin Feng, Dan Li, Chengfeng Wang, Xiaofeng Bai and Jianwei Zhang
    Citation: Biology Direct 2023 18:77
    Content type: Research Published on:

  39. Extracellular vesicles (EVs) derived from various cell sources exert cardioprotective effects during cardiac ischemic injury. Our previous study confirmed that EVs derived from ischemic-reperfusion injured hea...

    Authors: Xuan Liu, Shanshan Shi, Xuedi Geng, Enhao Wang, Qingshu Meng, Mimi Li, Fang Lin, Xiaoxue Ma, Wei Han and Xiaohui Zhou
    Citation: Biology Direct 2023 18:76
    Content type: Research Published on:

  40. Ligamentum flavum (LF) hypertrophy is the main cause of lumbar spinal canal stenosis (LSCS). Previous studies have shown that LF hypertrophy tissue exhibits abnormal lipid accumulation, but the regulatory mech...

    Authors: Yanlin Cao, Jianjun Li, Sujun Qiu, Songjia Ni and Yang Duan
    Citation: Biology Direct 2023 18:75
    Content type: Research Published on:

  41. Cancer stemness and osteosarcoma (OS) malignant progression are closely associated. However, the molecular mechanisms underlying this association have not been fully demonstrated. Long noncoding RNAs (lncRNAs)...

    Authors: Zhining Yang, Zhaoyong Liu, Weiqing Lu, Huancheng Guo, Jianzhou Chen and Ying Zhang
    Citation: Biology Direct 2023 18:74
    Content type: Research Published on:

  42. Head and neck squamous cell carcinoma (HNSCC) is characterized by high proliferation and limited differentiation. The altered expression of the p53 family members, and specifically of p63, represents a pivotal...

    Authors: Angela Cappello, Giulia Tosetti, Artem Smirnov, Carlo Ganini, Xue Yang, Yufang Shi, Ying Wang, Gerry Melino, Francesca Bernassola and Eleonora Candi
    Citation: Biology Direct 2023 18:73
    Content type: Research Published on:

  43. Malignant melanoma is a highly heterogeneous skin cancer with the highest mortality rate among dermatological cancers. Catenins form functional networks in the nucleus to regulate gene expression and determine...

    Authors: Yi-dou Hu, Ke Wu, Yuan-jie Liu, Qian Zhang, Hui Shen, Jin Ji, Dong Fang and Song-yang Xi
    Citation: Biology Direct 2023 18:72
    Content type: Research Published on:

  44. Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor i...

    Authors: Peng Liu, Liwei Zhao, Guido Kroemer and Oliver Kepp
    Citation: Biology Direct 2023 18:71
    Content type: Review Published on:

  45. The study aimed to identify transcripts of specific ion channels in rat ventricular cardiomyocytes and determine their potential role in the regulation of ionic currents in response to mechanical stimulation. ...

    Authors: Andre G. Kamkin, Olga V. Kamkina, Viktor E. Kazansky, Vadim M. Mitrokhin, Andrey Bilichenko, Elizaveta A. Nasedkina, Stanislav A. Shileiko, Anastasia S. Rodina, Alexandra D. Zolotareva, Valentin I. Zolotarev, Pavel V. Sutyagin and Mitko I. Mladenov
    Citation: Biology Direct 2023 18:70
    Content type: Research Published on:

  46. Bcl-B is a poorly understood protein of the Bcl-2 family that is highly expressed in many healthy tissues and tumor types. Bcl-B is considered an antiapoptotic protein, but many reports have revealed its contr...

    Authors: N. V. Pervushin, G. S. Kopeina and B. Zhivotovsky
    Citation: Biology Direct 2023 18:69
    Content type: Review Published on:

  48. Nuclear respiratory factor 1 (NRF1) is a transcription factor that participates in several kinds of tumor, but its role in hepatocellular carcinoma (HCC) remains elusive. This study aims to explore the role of...

    Authors: Ran Liu, Chuanzheng Yin, Peng Zhao, Bing Guo, Wenbo Ke, Xichuan Zheng, Dawei Xie, Yaofeng Wang, Gengqiao Wang, Yinzhao Jia, Yang Gao, Wenjun Hu, Gang Logan Liu and Zifang Song
    Citation: Biology Direct 2023 18:67
    Content type: Research Published on:

  49. The social impact of glaucoma is worth of note: primary open-angle glaucoma (POAG) is one of the leading causes of irreversible blindness worldwide, affecting some 68.56 million people with overall prevalence ...

    Authors: Damiana Scuteri, Giulio Pocobelli, Yoichi Sakurada, Rossella Russo, Paolo Tonin, Pierluigi Nicotera, Giacinto Bagetta, Maria Tiziana Corasaniti and Carlo Nucci
    Citation: Biology Direct 2023 18:66
    Content type: Review Published on:

  50. Kruppel-like factor 13 (KLF13) is a transcription factor and plays an important role in carcinogenesis. However, the significance of KLF13 in thyroid carcinoma (THCA) is underdetermined. In this study, we aime...

    Authors: Yang Liu, Yixuan Song, Yuqin He, Ziren Kong, Han Li, Yiming Zhu and Shaoyan Liu
    Citation: Biology Direct 2023 18:65
    Content type: Research Published on:
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