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  1. Discovery notes

    Cellular origin of the viral capsid-like bacterial microcompartments

    Bacterial microcompartments (BMC) are proteinaceous organelles that structurally resemble viral capsids, but encapsulate enzymes that perform various specialized biochemical reactions in the cell cytoplasm. Th...

    Mart Krupovic and Eugene V. Koonin

    Biology Direct 2017 12:25

    Published on: 13 November 2017

  2. Opinion

    Why we don’t want another “Synthesis”

    High-level debates in evolutionary biology often treat the Modern Synthesis as a framework of population genetics, or as an intellectual lineage with a changing distribution of beliefs. Unfortunately, these fl...

    Arlin Stoltzfus

    Biology Direct 2017 12:23

    Published on: 2 October 2017

  3. Research

    Evidence-based gene models for structural and functional annotations of the oil palm genome

    Oil palm is an important source of edible oil. The importance of the crop, as well as its long breeding cycle (10-12 years) has led to the sequencing of its genome in 2013 to pave the way for genomics-guided b...

    Kuang-Lim Chan, Tatiana V. Tatarinova, Rozana Rosli, Nadzirah Amiruddin, Norazah Azizi, Mohd Amin Ab Halim, Nik Shazana Nik Mohd Sanusi, Nagappan Jayanthi, Petr Ponomarenko, Martin Triska, Victor Solovyev, Mohd Firdaus-Raih, Ravigadevi Sambanthamurthi, Denis Murphy and Eng-Ti Leslie Low

    Biology Direct 2017 12:21

    Published on: 8 September 2017

  4. Research

    On the global CRISPR array behavior in class I systems

    Much effort is underway to build and upgrade databases and tools related to occurrence, diversity, and characterization of CRISPR-Cas systems. As microbial communities and their genome complements are unearthe...

    Alice Toms and Rodolphe Barrangou

    Biology Direct 2017 12:20

    Published on: 29 August 2017

  5. Research

    Bacterial tail anchors can target to the mitochondrial outer membrane

    During the generation and evolution of the eukaryotic cell, a proteobacterial endosymbiont was re-fashioned into the mitochondrion, an organelle that appears to have been present in the ancestor of all present...

    Güleycan Lutfullahoğlu-Bal, Abdurrahman Keskin, Ayşe Bengisu Seferoğlu and Cory D. Dunn

    Biology Direct 2017 12:16

    Published on: 24 July 2017

  6. Research

    TFAP2A is a component of the ZEB1/2 network that regulates TGFB1-induced epithelial to mesenchymal transition

    The transition between epithelial and mesenchymal phenotypes (EMT) occurs in a variety of contexts. It is critical for mammalian development and it is also involved in tumor initiation and progression. Master ...

    Yoana Dimitrova, Andreas J. Gruber, Nitish Mittal, Souvik Ghosh, Beatrice Dimitriades, Daniel Mathow, William Aaron Grandy, Gerhard Christofori and Mihaela Zavolan

    Biology Direct 2017 12:8

    Published on: 17 April 2017

  7. Review

    Post translational modification of Parkin

    Mutations in the gene encoding for the E3 ubiquitin ligase Parkin are associated to a rare form of familiar autosomal recessive Parkinsonism. Despite decades of research on the Parkin protein, whose structure ...

    Joy Chakraborty, Valentina Basso and Elena Ziviani

    Biology Direct 2017 12:6

    Published on: 21 February 2017

  8. Research

    Consistent metagenomic biomarker detection via robust PCA

    Recent developments of high throughput sequencing technologies allow the characterization of the microbial communities inhabiting our world. Various metagenomic studies have suggested using microbial taxa as p...

    Mustafa Alshawaqfeh, Ahmad Bashaireh, Erchin Serpedin and Jan Suchodolski

    Biology Direct 2017 12:4

    Published on: 31 January 2017

  9. Review

    Of yeast, mice and men: MAMs come in two flavors

    The past decade has seen dramatic progress in our understanding of membrane contact sites (MCS). Important examples of these are endoplasmic reticulum (ER)-mitochondria contact sites. ER-mitochondria contacts ...

    Maria Sol Herrera-Cruz and Thomas Simmen

    Biology Direct 2017 12:3

    Published on: 25 January 2017

  10. Research

    Thermodynamic and kinetic stability of the Josephin Domain closed arrangement: evidences from replica exchange molecular dynamics

    Molecular phenomena driving pathological aggregation in neurodegenerative diseases are not completely understood yet. Peculiar is the case of Spinocerebellar Ataxia 3 (SCA3) where the conformational properties...

    Gianvito Grasso, Jack A. Tuszynski, Umberto Morbiducci, Ginevra Licandro, Andrea Danani and Marco A. Deriu

    Biology Direct 2017 12:2

    Published on: 19 January 2017

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