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  1. During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue homeostasis and resulting in subsequent hyperplasia. This process is paralleled by resumption of cell cycle, aberrant D...

    Authors: Julian M. Rozenberg, Svetlana Zvereva, Aleksandra Dalina, Igor Blatov, Ilya Zubarev, Daniil Luppov, Alexander Bessmertnyi, Alexander Romanishin, Lamak Alsoulaiman, Vadim Kumeiko, Alexander Kagansky, Gerry Melino, Carlo Ganini and Nikolai A. Barlev

    Citation: Biology Direct 2021 16:23

    Content type: Review

    Published on:

  2. Rab32 is a small GTPase associated with multiple organelles but is particularly enriched at the endoplasmic reticulum (ER). Here, it controls targeting to mitochondria-ER contacts (MERCs), thus influencing com...

    Authors: Maria Sol Herrera-Cruz, Megan C. Yap, Nasser Tahbaz, Keelie Phillips, Laurel Thomas, Gary Thomas and Thomas Simmen

    Citation: Biology Direct 2021 16:22

    Content type: Research

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  3. Recently, overwhelming evidence supports that long noncoding RNAs (lncRNAs) play crucial roles in the occurrence and progression of tumors. However, the role and mechanism of lncRNA TFAP2A-AS1 in human gastric...

    Authors: Xin Zhao, Linlin Chen, Jingxun Wu, Jun You, Qingqi Hong and Feng Ye

    Citation: Biology Direct 2021 16:21

    Content type: Research

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  4. SARS-CoV-2 infection could cause severe acute respiratory syndrome, largely attributed to dysregulated immune activation and extensive lung tissue damage. However, the underlying mechanisms are not fully under...

    Authors: He Ren, Chaobing Ma, Haoran Peng, Bo Zhang, Lulin Zhou, Yan Su, Xiaoyan Gao and Hongyan Huang

    Citation: Biology Direct 2021 16:20

    Content type: Research

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  5. The knowledge of the history of a subject stimulates understanding. As we study how other people have made scientific breakthroughs, we develop the breadth of imagination that would inspire us to make new disc...

    Authors: Péter Poczai and Jorge A. Santiago-Blay

    Citation: Biology Direct 2021 16:19

    Content type: Review

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  6. Skeletal muscle has an extraordinary regenerative capacity reflecting the rapid activation and effective differentiation of muscle stem cells (MuSCs). In the course of muscle regeneration, MuSCs are reprogramm...

    Authors: Jiankai Fang, Chao Feng, Wangwang Chen, Pengbo Hou, Zhanhong Liu, Muqiu Zuo, Yuyi Han, Chenchang Xu, Gerry Melino, Alexei Verkhratsky, Ying Wang, Changshun Shao and Yufang Shi

    Citation: Biology Direct 2021 16:18

    Content type: Review

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  8. Human bone marrow-derived mesenchymal stem cells (hBMSCs) are the primary source of osteoblasts in vivo. Emerging literatures have unveiled that circular RNAs (circRNAs) are actively drawn in the osteogenic di...

    Authors: Yuansheng Huang, Su Wan and Min Yang

    Citation: Biology Direct 2021 16:16

    Content type: Research

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  9. The interaction between proteins is a fundamental event for cellular life that is generally mediated by specialized protein domains or modules. PDZ domains are the largest class of protein–protein interaction ...

    Authors: Caterina Nardella, Lorenzo Visconti, Francesca Malagrinò, Livia Pagano, Marianna Bufano, Marianna Nalli, Antonio Coluccia, Giuseppe La Regina, Romano Silvestri, Stefano Gianni and Angelo Toto

    Citation: Biology Direct 2021 16:15

    Content type: Review

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  10. The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the regulation of several cellular functions, including cell cycle progression and cell death in response to genotoxic st...

    Authors: Emanuele Panatta, Carlotta Zampieri, Gerry Melino and Ivano Amelio

    Citation: Biology Direct 2021 16:14

    Content type: Opinion

    Published on:

  11. Growing evidence has demonstrated that long non-coding RNAs (lncRNAs) can function as modulators in the development of triple-negative breast cancer (TNBC). However, the function of lncRNA small nucleolar RNA ...

    Authors: Jintao Qian, Xinhan Lei, Yue Sun, Lu Zheng, Jia Li, Shuai Zhang, Lei Zhang, Wanwan Li, Jianing Shi, Wenjun Jia and Tong Tang

    Citation: Biology Direct 2021 16:13

    Content type: Research

    Published on:

  13. Most inactivating mutations in TP53 gene generates neomorphic forms of p53 proteins that experimental evidence and clinical observations suggest to exert gain-of-function effects. While massive effort has been...

    Authors: Eleonora Mammarella, Carlotta Zampieri, Emanuele Panatta, Gerry Melino and Ivano Amelio

    Citation: Biology Direct 2021 16:11

    Content type: Research

    Published on:

  14. Long-chain acyl-CoA synthetase-4 (ACSL4) is involved in fatty acid metabolism, and aberrant ACSL4 expression could be either tumorigenic or tumor-suppressive in different tumor types. However, the function and...

    Authors: Yixiang Zhang, Songyu Li, Fengzhou Li, Changsheng Lv and Qing-kai Yang

    Citation: Biology Direct 2021 16:10

    Content type: Research

    Published on:

  15. Cancer is a major health problem which presents a high heterogeneity. In this work we explore omics data from Breast, Kidney and Lung cancers at different levels as signalling pathways, functions and miRNAs, a...

    Authors: Sergio Romera-Giner, Zoraida Andreu Martínez, Francisco García-García and Marta R. Hidalgo

    Citation: Biology Direct 2021 16:9

    Content type: Research

    Published on:

  16. Human aromatase is a member of the cytochrome P450 superfamily, involved in steroid hormones biosynthesis. In particular, it converts androgen into estrogens being therefore responsible for the correct sex ste...

    Authors: Giovanna Di Nardo, Almerinda Di Venere, Chao Zhang, Eleonora Nicolai, Silvia Castrignanò, Luisa Di Paola, Gianfranco Gilardi and Giampiero Mei

    Citation: Biology Direct 2021 16:8

    Content type: Research

    Published on:

  18. Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and mod...

    Authors: Anika Liu, Moritz Walter, Peter Wright, Aleksandra Bartosik, Daniela Dolciami, Abdurrahman Elbasir, Hongbin Yang and Andreas Bender

    Citation: Biology Direct 2021 16:6

    Content type: Research

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  19. Drug-induced liver injury (DILI) is an adverse reaction caused by the intake of drugs of common use that produces liver damage. The impact of DILI is estimated to affect around 20 in 100,000 inhabitants worldw...

    Authors: Joaquim Aguirre-Plans, Janet Piñero, Terezinha Souza, Giulia Callegaro, Steven J. Kunnen, Ferran Sanz, Narcis Fernandez-Fuentes, Laura I. Furlong, Emre Guney and Baldo Oliva

    Citation: Biology Direct 2021 16:5

    Content type: Research

    Published on:

  20. The human proteins TMTC1, TMTC2, TMTC3 and TMTC4 have been experimentally shown to be components of a new O-mannosylation pathway. Their own mannosyl-transferase activity has been suspected but their actual en...

    Authors: Birgit Eisenhaber, Swati Sinha, Chaitanya K. Jadalanki, Vladimir A. Shitov, Qiao Wen Tan, Fernanda L. Sirota and Frank Eisenhaber

    Citation: Biology Direct 2021 16:4

    Content type: Research

    Published on:

  22. Drug-induced liver injury (DILI) is one of the primary problems in drug development. Early prediction of DILI can bring a significant reduction in the cost of clinical trials. In this work we examined whether ...

    Authors: Wojciech Lesiński, Krzysztof Mnich, Agnieszka Kitlas Golińska and Witold R. Rudnicki

    Citation: Biology Direct 2021 16:2

    Content type: Research

    Published on:

  23. Composition of microbial communities can be location-specific, and the different abundance of taxon within location could help us to unravel city-specific signature and predict the sample origin locations accu...

    Authors: Runzhi Zhang, Alejandro R. Walker and Susmita Datta

    Citation: Biology Direct 2021 16:1

    Content type: Research

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  24. Knowing the “point of view” of the immune system is essential to understand the characteristic of a pandemic, such as that generated by the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2, responsib...

    Authors: Ivana Celardo, Luigia Pace, Loredana Cifaldi, Carlo Gaudio and Vincenzo Barnaba

    Citation: Biology Direct 2020 15:30

    Content type: Review

    Published on:

  28. Many hypotheses have been proposed for how sexual reproduction may facilitate an increase in the population mean fitness, such as the Fisher-Muller theory, Muller’s ratchet and others. According to the recentl...

    Authors: Liudmyla Vasylenko, Marcus W. Feldman and Adi Livnat

    Citation: Biology Direct 2020 15:26

    Content type: Research

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  29. Aetiogenesis of cancer has not been fully determined. Recent advances have clearly defined a role for microenvironmental factors in cancer progression and initiation; in this context, microbiome has recently e...

    Authors: Ivana Celardo, Gerry Melino and Ivano Amelio

    Citation: Biology Direct 2020 15:25

    Content type: Review

    Published on:

  31. Chron’s Disease is a chronic inflammatory intestinal disease, first described at the beginning of the last century. The disease is characterized by the alternation of periods of flares and remissions influence...

    Authors: L. Petagna, A. Antonelli, C. Ganini, V. Bellato, M. Campanelli, A. Divizia, C. Efrati, M. Franceschilli, A. M. Guida, S. Ingallinella, F. Montagnese, B. Sensi, L. Siragusa and G. S. Sica

    Citation: Biology Direct 2020 15:23

    Content type: Review

    Published on:

  33. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection spreaded rapidly worldwide, as far as it has become a global pandemic. Therefore, the introduction of serological tests for determination ...

    Authors: Annalisa Noce, Maria Luisa Santoro, Giulia Marrone, Cartesio D’Agostini, Ivano Amelio, Andrea Duggento, Manfredi Tesauro and Nicola Di Daniele

    Citation: Biology Direct 2020 15:21

    Content type: Research

    Published on:

  34. The nematode worm, Caenorhabditis elegans, is a saprophytic species that has been emerging as a standard model organism since the early 1960s. This species is useful in numerous fields, including developmental bi...

    Authors: Peng-Cheng Chen, Li Ruan, Jie Jin, Yu-Tian Tao, Xiao-Bao Ding, Hai-bo Zhang, Wen-Ping Guo, Qiao-lei Yang, Heng Yao and Xin Chen

    Citation: Biology Direct 2020 15:20

    Content type: Research

    Published on:

  36. The identification of individual or clusters of predictive genetic alterations might help in defining the outcome of cancer treatment, allowing for the stratification of patients into distinct cohorts for sele...

    Authors: Ivano Amelio, Riccardo Bertolo, Pierluigi Bove, Eleonora Candi, Marcello Chiocchi, Chiara Cipriani, Nicola Di Daniele, Carlo Ganini, Hartmut Juhl, Alessandro Mauriello, Carla Marani, John Marshall, Manuela Montanaro, Giampiero Palmieri, Mauro Piacentini, Giuseppe Sica…

    Citation: Biology Direct 2020 15:18

    Content type: Review

    Published on:

  40. The transamidase complex is a molecular machine in the endoplasmic reticulum of eukaryotes that attaches a glycosylphosphatidylinositol (GPI) lipid anchor to substrate proteins after cleaving a C-terminal prop...

    Authors: Chinh Tran-To Su, Swati Sinha, Birgit Eisenhaber and Frank Eisenhaber

    Citation: Biology Direct 2020 15:14

    Content type: Research

    Published on:

  41. Inferring the mechanisms that drive transcriptional regulation is of great interest to biologists. Generally, methods that predict physical interactions between transcription factors (TFs) based on positional ...

    Authors: Stefano Perna, Pietro Pinoli, Stefano Ceri and Limsoon Wong

    Citation: Biology Direct 2020 15:13

    Content type: Research

    Published on:

  42. AMDock (Assisted Molecular Docking) is a user-friendly graphical tool to assist in the docking of protein-ligand complexes using Autodock Vina and AutoDock4, including the option of using the Autodock4Zn force...

    Authors: Mario S. Valdés-Tresanco, Mario E. Valdés-Tresanco, Pedro A. Valiente and Ernesto Moreno

    Citation: Biology Direct 2020 15:12

    Content type: Application note

    Published on:

  43. LINC00426 is a newly identified long non-coding RNA (lncRNA) with unacknowledged biological roles. Here we set out to characterize the expression status of LINC00426 in osteosarcoma and understand its mechanis...

    Authors: Lulin Wang, Yi Luo, Yiquan Zheng, Lifeng Zheng, Wenxiang Lin, Zonglin Chen, Shichun Wu, Jinhong Chen and Yun Xie

    Citation: Biology Direct 2020 15:11

    Content type: Research

    Published on:

  44. Glioma is one of the most common malignant brain tumors and exhibits low resection rate and high recurrence risk. Although a large number of glioma studies powered by high-throughput sequencing technologies ha...

    Authors: Lin Liu, Guangyu Wang, Liguo Wang, Chunlei Yu, Mengwei Li, Shuhui Song, Lili Hao, Lina Ma and Zhang Zhang

    Citation: Biology Direct 2020 15:10

    Content type: Research

    Published on:

  45. The origin of the selective nuclear protein import machinery, which consists of nuclear pore complexes and adaptor molecules interacting with the nuclear localization signals (NLSs) of cargo molecules, is one ...

    Authors: Olga M. Lisitsyna, Margarita A. Kurnaeva, Eugene A. Arifulin, Maria Y. Shubina, Yana R. Musinova, Andrey A. Mironov and Eugene V. Sheval

    Citation: Biology Direct 2020 15:9

    Content type: Research

    Published on:

  48. Accurate classification of different Burkholderia cepacia complex (BCC) species is essential for therapy, prognosis assessment and research. The taxonomic status of BCC remains problematic and an improved knowled...

    Authors: Yuan Jin, Jianglin Zhou, Jing Zhou, Mingda Hu, Qi Zhang, Na Kong, Hongguang Ren, Long Liang and Junjie Yue

    Citation: Biology Direct 2020 15:6

    Content type: Research

    Published on:

  49. Until recently, our planet was thought to be home to ~ 107 species, largely belonging to plants and animals. Despite being the most abundant organisms on Earth, the contribution of microbial life to global biodiv...

    Authors: Jay T. Lennon and Kenneth J. Locey

    Citation: Biology Direct 2020 15:5

    Content type: Comment

    Published on:

  50. Drug-induced liver injury (DILI) is a major concern in drug development, as hepatotoxicity may not be apparent at early stages but can lead to life threatening consequences. The ability to predict DILI from in...

    Authors: Marco Chierici, Margherita Francescatto, Nicole Bussola, Giuseppe Jurman and Cesare Furlanello

    Citation: Biology Direct 2020 15:3

    Content type: Research

    Published on:

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