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  1. Despite improvements in prognosis due to advances in treatment, including surgery, genetic screening, and molecular targeted therapy, the outcomes of ovarian cancer (OC) remain unsatisfactory. Internal mRNA mo...

    Authors: Lijuan Gan, Shengchao Zhao, Yang Gao, Yuwen Qi, Min Su, Anjin Wang and Hongbing Cai
    Citation: Biology Direct 2023 18:64
    Content type: Research Published on:

  2. Anthracyclines including doxorubicin are essential components of many cancer chemotherapy regimens, but their cardiotoxicity severely limits their use. New strategies for treating anthracycline-induced cardiot...

    Authors: Xuechun Chen, Changtong Liu, Hong Zhao, Yigang Zhong, Yizhou Xu and Yi Wang
    Citation: Biology Direct 2023 18:63
    Content type: Research Published on:

  3. Authors: Salwa Soussi, Lesia Savchenko, Davide Rovina, Jason S. Iacovoni, Andrea Gottinger, Maxime Vialettes, Josè-Manuel Pioner, Andrea Farini, Sara Mallia, Martina Rabino, Giulio Pompilio, Angelo Parini, Olivier Lairez, Aoife Gowran and Nathalie Pizzinat
    Citation: Biology Direct 2023 18:62
    Content type: Correction Published on:

    The original article was published in Biology Direct 2023 18:41

  4. Severe traumatic brain injury (TBI) is one of the most dramatic events in pediatric age and, despite advanced neuro-intensive care, the survival rate of these patients remains low. Children suffering from seve...

    Authors: Antonio Gatto, Lavinia Capossela, Giorgio Conti, Gemma Eftimiadi, Serena Ferretti, Luigi Manni, Antonietta Curatola, Benedetta Graglia, Lorenzo Di Sarno, Maria Lucia Calcagni, Daniela Di Giuda, Stefano Cecere, Domenico Marco Romeo, Marzia Soligo, Enzo Picconi, Marco Piastra…
    Citation: Biology Direct 2023 18:61
    Content type: Research Published on:

  5. Peroxisomes play a central role in tuning metabolic and signaling programs in a tissue- and cell-type-specific manner. However, the mechanisms by which the status of peroxisomes is communicated and integrated ...

    Authors: Akihiro Yamashita, Olesia Ignatenko, Mai Nguyen, Raphaëlle Lambert, Kathleen Watt, Caroline Daneault, Isabelle Robillard-Frayne, Ivan Topisirovic, Christine Des Rosiers and Heidi M. McBride
    Citation: Biology Direct 2023 18:60
    Content type: Research Published on:

  6. The thymus is required for T cell development and the formation of the adaptive immunity. Stromal cells, which include thymic epithelial cells (TECs) and mesenchymal stromal cells (MSCs), are essential for thy...

    Authors: Xiao Su, Xiaolei Li, Shiqing Wang, Xiaotong Xue, Rui Liu, Xiaojing Bai, Pixia Gong, Chao Feng, Lijuan Cao, Tingting Wang, Yayun Ding, Junjie Jiang, Yongjing Chen, Yufang Shi and Changshun Shao
    Citation: Biology Direct 2023 18:59
    Content type: Research Published on:

  8. Spinal muscular atrophy (SMA) is a rare autosomal-recessive neurodegenerative disorder caused by mutations in survival motor neuron 1 (SMN1) gene, and consequent loss of function of SMN protein, which results in ...

    Authors: M. Garofalo, S. Bonanno, S. Marcuzzo, C. Pandini, E. Scarian, F. Dragoni, R. Di Gerlando, M. Bordoni, S. Parravicini, C. Gellera, R. Masson, C. Dosi, R. Zanin, O. Pansarasa, C. Cereda, A. Berardinelli…
    Citation: Biology Direct 2023 18:57
    Content type: Research Published on:

  9. Tumor-associated macrophages (TAMs) are an important subset of innate immune cells in the tumor microenvironment, and they are pivotal regulators of tumor-promoting inflammation and tumor progression. Evidence...

    Authors: Yandong Zhang, Shu Ma, Tie Li, Yu Tian, Huangao Zhou, Hongsheng Wang and Lan Huang
    Citation: Biology Direct 2023 18:56
    Content type: Research Published on:

    The Correction to this article has been published in Biology Direct 2023 18:83

  11. Perilipin 5 (Plin5) is well known to maintain the stability of intracellular lipid droplets (LDs) and regulate fatty acid metabolism in oxidative tissues. It is highly expressed in the heart, but its roles hav...

    Authors: Lele Jian, Xing Gao, Chao Wang, Xiao Sun, Yuqiao Xu, Ruili Han, Yuying Wang, Shenhui Xu, Lan Ding, Jingjun Zhou, Yu Gu, Yuanlin Zhao, Ying Yang, Yuan Yuan, Jing Ye and Lijun Zhang
    Citation: Biology Direct 2023 18:54
    Content type: Research Published on:

  12. Hepatocellular carcinoma (HCC) is one of the most common and challenging cancers in the world. N6-methyladenosine (m6A) modification and long non-coding RNAs (lncRNAs) play critical roles in the progression of HC...

    Authors: Runkun Liu, Guozhi Yin, Hang Tuo, Yixian Guo, Yifeng Zhu, Lei Zhang, Wei Yang, Qingguang Liu and Yufeng Wang
    Citation: Biology Direct 2023 18:53
    Content type: Research Published on:

  14. Helicobacter pylori (H.pylori, HP) is one of the main causes of gastric cancer (GC). CircRNAs have been reported to play a crucial role in developing many types of cancer. However, the role of circRNAs in the dev...

    Authors: Yun Liu, Jia Cao, Qi Yang, Linqi Zhu, Wenjun Zhao, Xiuping Wang, Jun Yao, Yong Zhou and Shihe Shao
    Citation: Biology Direct 2023 18:51
    Content type: Research Published on:

  15. The response rate to obeticholic acid (OCA), a potential therapeutic agent for non-alcoholic fatty liver disease, is limited. This study demonstrated that upregulation of the alternative bile acid synthesis pa...

    Authors: Seung Min Lee, Dae Won Jun, Eileen Laurel Yoon, Ju Hee Oh, Yoon Jin Roh, Eun Jeoung Lee, Ji-Hee Shin, Young-Do Nam and Hyun Sung Kim
    Citation: Biology Direct 2023 18:50
    Content type: Research Published on:

  16. The light-harvesting antennae of photosystem (PS) I and PSII are pigment-protein complexes responsible of the initial steps of sunlight conversion into chemical energy. In natural environments plants are const...

    Authors: Edoardo Andrea Cutolo, Roberto Caferri, Zeno Guardini, Luca Dall’Osto and Roberto Bassi
    Citation: Biology Direct 2023 18:49
    Content type: Research Published on:

  17. Circular RNAs (circRNAs) have been shown to play diverse biological functions in the progression of multiple diseases. However, the impacts of circRNAs on breast cancer (BC) progression remains unclear. Theref...

    Authors: Juan Li, Xiangjun Dong, Xue Kong, Yafen Wang, Yanru Li, Yao Tong, Wenjing Zhao, Weili Duan, Peilong Li, Yanqun Wang and Chuanxin Wang
    Citation: Biology Direct 2023 18:48
    Content type: Research Published on:

  18. C-to-U RNA editing in plants is believed to confer its evolutionary adaptiveness by reversing unfavorable DNA mutations. This “restorative hypothesis” has not yet been tested genome-wide. In contrast, A-to-I R...

    Authors: Yuange Duan, Ye Xu, Fan Song, Li Tian, Wanzhi Cai and Hu Li
    Citation: Biology Direct 2023 18:47
    Content type: Hypothesis Published on:

  20. It is generally accepted that most evolutionary transformations at the phenotype level are associated either with rearrangements of genomic regulatory elements, which control the activity of gene networks, or ...

    Authors: Vassily A. Lyubetsky, Lev I. Rubanov, Maria B. Tereshina, Anastasiya S. Ivanova, Karina R. Araslanova, Leonid A. Uroshlev, Galina I. Goremykina, Jian-Rong Yang, Vladimir G. Kanovei, Oleg A. Zverkov, Alexander D. Shitikov, Daria D. Korotkova and Andrey G. Zaraisky
    Citation: Biology Direct 2023 18:45
    Content type: Research Published on:

  21. Patients with triple-negative breast cancer (TNBC) tend to develop visceral metastasis within five years, making them the most challenging BC patients to treat. The MAP7 protein family is a group of microtubul...

    Authors: Wen-Hung Kuo, Pei-Yi Chu, Chen-Chi Wang, Ping-Shen Huang and Shih-Hsuan Chan
    Citation: Biology Direct 2023 18:44
    Content type: Research Published on:

  22. Antipsychotic drugs are the mainstay of treatment for schizophrenia and provide adjunct therapies for other prevalent psychiatric conditions, including bipolar disorder and major depressive disorder. However, ...

    Authors: Rachel E. Hardy, Injae Chung, Yizhou Yu, Samantha H. Y. Loh, Nobuhiro Morone, Clement Soleilhavoup, Marco Travaglio, Riccardo Serreli, Lia Panman, Kelvin Cain, Judy Hirst, Luis M. Martins, Marion MacFarlane and Kenneth R. Pryde
    Citation: Biology Direct 2023 18:43
    Content type: Research Published on:

  23. Volumetric Muscle Loss (VML), resulting from severe trauma or surgical ablation, is a pathological condition preventing myofibers regeneration, since skeletal muscle owns the remarkable ability to restore tiss...

    Authors: Francesca De Paolis, Stefano Testa, Gabriele Guarnaccia, Alessio Reggio, Ersilia Fornetti, Felice Cicciarelli, Rebecca Deodati, Sergio Bernardini, Daniele Peluso, Jacopo Baldi, Roberto Biagini, Flavia Cobianchi Bellisari, Antonio Izzo, Ferruccio Sgalambro, Francesco Arrigoni, Francesco Rizzo…
    Citation: Biology Direct 2023 18:42
    Content type: Research Published on:

  24. Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy caused by mutations in the dystrophin gene. We characterized which isoforms of dystrophin were expressed by human induced pluripotent st...

    Authors: Salwa Soussi, Lesia Savchenko, Davide Rovina, Jason S. Iacovoni, Andrea Gottinger, Maxime Vialettes, Josè-Manuel Pioner, Andrea Farini, Sara Mallia, Martina Rabino, Giulio Pompilio, Angelo Parini, Olivier Lairez, Aoife Gowran and Nathalie Pizzinat
    Citation: Biology Direct 2023 18:41
    Content type: Research Published on:

    The Correction to this article has been published in Biology Direct 2023 18:62

  25. Natural ageing of organisms and corresponding age-related diseases result mainly from stem cell ageing and “inflammaging”. Mesenchymal stem cells (MSCs) exhibit very high immune-regulating capacity and are pro...

    Authors: Xue Yang, Ying Wang, Valentina Rovella, Eleonora Candi, Wei Jia, Francesca Bernassola, Pierluigi Bove, Mauro Piacentini, Manuel Scimeca, Giuseppe Sica, Giuseppe Tisone, Alessandro Mauriello, Lixin Wei, Gerry Melino and Yufang Shi
    Citation: Biology Direct 2023 18:40
    Content type: Review Published on:

  26. Previously, we identified an oncogenic splicing variant of DOCK5 in head and neck squamous cell carcinoma (HNSCC); however, the mechanism for the generation of this specific DOCK5 variant remains unknown. This...

    Authors: Chao Liu, Guo Li, Siyuan Zheng, Li She, Shanhong Lu, Yunyun Wang, Donghai Huang, Xin Zhang, Lunquan Sun, Yong Liu and Yuanzheng Qiu
    Citation: Biology Direct 2023 18:39
    Content type: Research Published on:

  27. Prostate cancer remains one of the deadliest neoplasms in developed countries. Identification of new molecular markers that predict the onset and progression of the disease could improve its clinical managemen...

    Authors: Matthieu Le Hars, Luis Jaime Castro-Vega, Fatemeh Rajabi, David Tabatadze, Martha Romero, Marina Pinskaya and Irina Groisman
    Citation: Biology Direct 2023 18:38
    Content type: Comment Published on:

  28. Intervertebral disc degeneration (IDD) naturally occurs during the aging process. Its occurrence is closely related to chronic inflammation; however, the causal relationship between them is controversial. This...

    Authors: Xingguo Li, Jun Zhang, Bing Wang, Chao Chen, Enyu Zhang, Zhengpin Lv, Qicong He, Yaoquan Hu, Xuenan Wang and Fan Zhang
    Citation: Biology Direct 2023 18:37
    Content type: Research Published on:

  29. LncRNA PSMA3-AS1 functions as an oncogene in several cancers, including ovarian cancer, lung cancer, and colorectal cancer. However, its role in gastric cancer (GC) progression remains unclear. In this study, ...

    Authors: Liang Kan, Meiqi Yang and Huijing Zhang
    Citation: Biology Direct 2023 18:36
    Content type: Research Published on:

  30. Bicuspid aortic valve (BAV) is the most prevalent congenital valvular heart defect, and around 50% of severe isolated calcific aortic valve disease (CAVD) cases are associated with BAV. Although previous studi...

    Authors: Tao Lyu, Yang Liu, Binglin Li, Ran Xu, Jianghong Guo and Dan Zhu
    Citation: Biology Direct 2023 18:35
    Content type: Research Published on:

  31. Tooth development, as one of the major mineralized tissues in the body, require fine-tuning of mineralization micro-environment. The interaction between dental epithelium and mesenchyme plays a decisive role i...

    Authors: MengDan Zhang, Junming Zheng, Siyuan Wu, Hailing Chen and Lusai Xiang
    Citation: Biology Direct 2023 18:34
    Content type: Research Published on:

  33. Adipose tissue, an organ critical for systemic energy homeostasis, is influenced by type 2 immunity in its development and function. The type 2 cytokine interleukin (IL)-4 induces the proliferation of bipotent...

    Authors: Choijamts Munkhzul, Ji-Min Lee, Boseon Kim, Thi Thanh My Nguyen, Rehna Paula Ginting, Dahee Jeong, Young-Kook Kim, Min-Woo Lee and Mihye Lee
    Citation: Biology Direct 2023 18:32
    Content type: Research Published on:

  34. Male factors-caused decline in total fertility has raised significant concern worldwide. LncRNAs have been identified to play various roles in biological systems, including spermatogenesis. This study aimed to...

    Authors: Cong Zhang, Dongxin Lu, Tong Niu, Zhongyi Sun, Yandi Wang, Xiao Han, Bohui Xiong, Wei Shen, Qingyuan Sun, Yong Zhao, Weidong Zhang and Yanni Feng
    Citation: Biology Direct 2023 18:31
    Content type: Research Published on:

  35. Two-dimensional ultrathin Ti3C2 nanosheets are increasingly being used in biomedical applications owing to their special physicochemical properties. But, the biological effects of its exposure on the reproductive...

    Authors: Yang Wei, Ruilin Bao, Le Hu, Yanqing Geng, Xuemei Chen, Yixian Wen, Yingxiong Wang, Mao Qin, Yue Zhang and Xueqing Liu
    Citation: Biology Direct 2023 18:30
    Content type: Research Published on:

  36. Intermittent hypoxia is the best predictor of developing cognitive decline and Alzheimer’s disease progression in patients with obstructive sleep apnea. The nucleotide-binding oligomerization domain-like recep...

    Authors: Yaodan Zhang, Yuyang Miao, Xiangyang Xiong, Jin Tan, Zhaoli Han, Fanglian Chen, Ping Lei and Qiang Zhang
    Citation: Biology Direct 2023 18:29
    Content type: Research Published on:

  37. The predominant cancer-related deaths worldwide are caused by lung cancer, particularly non-small cell lung cancer (NSCLC), despite the fact that numerous therapeutic initiatives have been devised to improve t...

    Authors: Hanqing Zhao, Yanbo Wang, Yaomei He, Peng Zhang, Cheng Zeng, Tongxuan Du, Qiushuo Shen and Song Zhao
    Citation: Biology Direct 2023 18:28
    Content type: Research Published on:

  38. Long non-coding RNAs (lncRNAs) play important roles in the progression of glioma. Here, we examined the potential functions of a lncRNA, LINC01003, in glioma and characterized the underlying molecular mechanis...

    Authors: Xiaolong Zhu, Xingwei Wu, Hui Yang, Qiancheng Xu, Mengying Zhang, Xiaocen Liu and Kun Lv
    Citation: Biology Direct 2023 18:27
    Content type: Research Published on:

  39. The human genome contains nearly 20.000 protein-coding genes, but there are still more than 6,000 proteins poorly characterized. Among them, ZNF330/NOA36 stand out because it is a highly evolutionarily conserv...

    Authors: Alejandra Sanchez-Briñas, Carmen Duran-Ruiz, Antonio Astola, Marta Marina Arroyo, Fátima G. Raposo, Antonio Valle and Jorge Bolivar
    Citation: Biology Direct 2023 18:26
    Content type: Research Published on:

  40. Increasing evidences have shown that long non-coding RNAs (lncRNAs) display crucial regulatory roles in the occurrence and development of numerous diseases. However, the function and underlying mechanisms of l...

    Authors: Yanlin Cao, Jianjun Li, Sujun Qiu, Songjia Ni and Yang Duan
    Citation: Biology Direct 2023 18:25
    Content type: Research Published on:

  41. Out-of-hospital cardiac arrest (OHCA) is one of the most dramatic events in pediatric age and, despite advanced neurointensive care, the survival rate remains low. Currently, no effective treatments can restor...

    Authors: Antonietta Curatola, Benedetta Graglia, Giuseppe Granata, Giorgio Conti, Lavinia Capossela, Luigi Manni, Serena Ferretti, Daniela Di Giuda, Domenico Marco Romeo, Maria Lucia Calcagni, Marzia Soligo, Enrico Castelli, Marco Piastra, Flavio Mantelli, Giacomo Della Marca, Susanna Staccioli…
    Citation: Biology Direct 2023 18:24
    Content type: Research Published on:

  42. Hypertriglyceridemia (HTG) is one of the common causes of acute pancreatitis (AP). Hyperlipidemic acute pancreatitis (HTG-AP) is associated with higher mortality owing to its tendency for greater severity and ...

    Authors: Biwei Wei, Zhou Su, Huiying Yang, Yong Feng, Chunmei Meng and Zhihai Liang
    Citation: Biology Direct 2023 18:23
    Content type: Research Published on:

  43. Synapse diversity has been described from different perspectives, ranging from the specific neurotransmitters released, to their diverse biophysical properties and proteome profiles. However, synapse diversity...

    Authors: Amparo Roig Adam, José A. Martínez-López, Sophie J. F. van der Spek, Patrick F. Sullivan, August B. Smit, Matthijs Verhage and Jens Hjerling-Leffler
    Citation: Biology Direct 2023 18:22
    Content type: Research Published on:

  44. Rhynchophylline (RHY) is an alkaloid component of Uncaria, which are plants extensively used in traditional Asian medicines. Uncaria treatments increase sleep time and quality in humans, and RHY induces sleep ...

    Authors: Maria Neus Ballester Roig, Tanya Leduc, Julien Dufort-Gervais, Yousra Maghmoul, Olivier Tastet and Valérie Mongrain
    Citation: Biology Direct 2023 18:21
    Content type: Research Published on:

  45. The eukaryotic membrane vesicles contain specific sets of proteins that determine vesicle function and shuttle with specific destination. Giardia lamblia contains unknown cytosolic vesicles that are related to th...

    Authors: Jui-Hsuan Wu, Jen-Chi Lee, Chun-Che Ho, Pei-Wei Chiu and Chin-Hung Sun
    Citation: Biology Direct 2023 18:20
    Content type: Research Published on:

  46. Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive system, ranking third for morbidity and mortality worldwide. At present, no effective control method is available for this ca...

    Authors: Tian-yue Liu, Chen-chen Hu, Chen-ying Han, Si-yi Mao, Wen-xin Zhang, Yi-ming Xu, Yuan-jie Sun, Dong-bo Jiang, Xi-yang Zhang, Jia-xing Zhang, Jing Wang, Xu-peng Qiao, Jing-yu Pan, Shu-ya Yang and Kun Yang
    Citation: Biology Direct 2023 18:19
    Content type: Research Published on:

  47. TM4SF1, a member of the transmembrane 4 superfamily, is crucial for both healthy and malignant human tissues. The significant function of TM4SF1 in the incidence and progression of cancer has been widely recog...

    Authors: Si-bo Yang, Zi-han Zhou, Jin Lei, Xiao-wen Li, Qian Chen, Bo Li, Ye-wei Zhang, Yu-zhen Ge and Shi Zuo
    Citation: Biology Direct 2023 18:18
    Content type: Research Published on:

  48. Malignant mesothelioma (MM) is a rare tumor with a dismal prognosis. The low efficacy of current treatment options highlights the urge to identify more effective therapies aimed at improving MM patients’ survi...

    Authors: Monica Benvenuto, Valentina Angiolini, Chiara Focaccetti, Daniela Nardozi, Camilla Palumbo, Raffaele Carrano, Alessandra Rufini, Riccardo Bei, Martino Tony Miele, Patrizia Mancini, Giovanni Barillari, Mara Cirone, Elisabetta Ferretti, Grazia Raffaella Tundo, Luciano Mutti, Laura Masuelli…
    Citation: Biology Direct 2023 18:17
    Content type: Research Published on:

  49. With the rapidly increasing morbidity and mortality, lung cancer has been considered one of the serious malignant tumors, affecting millions of patients globally. Currently, the pathogenesis of lung cancer rem...

    Authors: Lei Cao, Hongsheng Liu, Cheng Huang, Chao Guo, Luo Zhao, Chao Gao, Yuan Xu, Guige Wang, Naixin Liang and Shanqing Li
    Citation: Biology Direct 2023 18:16
    Content type: Research Published on:

  50. Accumulating studies have demonstrated that the Warburg effect plays a central role in the occurrence and development of hepatocellular carcinoma (HCC), albeit the role of non-coding RNA (lncRNA) in its associ...

    Authors: Chuanjiang Liu, Kequan Xu, Jiayin Liu, Chao He, Pan Liu, Qiang Fu, Hongwei Zhang and Tao Qin
    Citation: Biology Direct 2023 18:15
    Content type: Research Published on:
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  • Citation Impact 2023
    Journal Impact Factor: 5.7
    5-year Journal Impact Factor: 4.5
    Source Normalized Impact per Paper (SNIP): 1.060
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