Table 4 The MPR3 moonlighting protein dataset

P79149/Pinin

Canis familiaris

Induce junction formation and enhance cell aggregation

Component of the RNP structure

[128]

P27487/DPP4

Homo sapiens

Serine protease

1. Cell surface glycoprotein receptor for CAV1

[129]

2. Co-stimulatory protein involving in T-cell receptor-mediated T-cell activation and proliferation.

3. Binding collagen and fibronectin

4. Involvement in apoptosis

Q91XR9/GPx-4

Mus musculus

Antioxidant of mature sperm

Structural protein of the mitochondrial capsule

[130]

O35242/FAN

Mus musculus

Apoptosis

Inflammatory signalling

[131]

E3D2R2/Fructose-1, 6-bisphosphate aldolase

Neisseria meningitidis

Glycolytic enzyme

Host-cell invasion

[132]

Q7L0Y3/MRP1

Homo sapiens

tRNA methyltransferase

Dehydrogenase

[133]

Q9Y7F0/Peroxiredoxin TSA1

Candida albicans

Antioxidant against sulfur-containing radicals

Involved in morphology

[134]

P48237/CCM1

Saccharomyces cerevisiae

Introns removal in mRNA maturation

Maintains the steady-state levels of the mitoribosome small subunit RNA

[135]

P11325/Nam2p

Saccharomyces cerevisiae

Mitochondrial leucyl-tRNA synthetase

Mitochondrial RNA splicing activity

[136]

Q9P2J5/LeuRS

Homo sapiens

tRNA synthetase

Translocation and activation of mTORC1 to lysosomal membrane

[137]

P47897/GlnRS

Homo sapiens

tRNA synthetase

Suppresses apoptotic acitivities

[137]

Q6DRC0/SerRS

Danio rerio

tRNA synthetase

Regulates development of closed circulatory system

[137]-[139]

P00883/Fructose-bisphosphate aldolase A

Oryctolagus cuniculus

Glycolytic enzyme

Regulation of cell mobility

[140]

P0A518/Cpn60-1

Mycobacterium tuberculosis

Prototypic molecular chaperone

Osteoclast-inhibitory action

[141]

P0A518/Cpn60-2

Mycobacterium tuberculosis

Prototypic molecular chaperone

Stimulates macrophage pro-inflammatory cytokine synthesis

[141]