Figure 2

Partial Regulatory Network of Swi6. A sub-network showing some of the new predictions for Swi6 and how they are interconnected to previously known targets, using public datasets in the VisAnt browser. Rfx1 and YMR279C are underlined in the network. The types of data used in network construction are indicated. The VisAnt toolkit [20, 21] shows links which come from many publications. Any particular type of link (e.g., protein-protein interaction) may represent a collection of data from several genomic datasets. Each link type is referred to in VisAnt as a "method" and each method has a unique identifier. The method IDs for the link types here include: M0037(phylogenetic profile), M0013(copurification), M0040(screened yeast-2-hybrid), M0031(other biophysical), M0046(Bayesian Predicted Interaction), M0045(affinity chromatography). Complete references and datasets are available in the VisAnt suite accessible from the website [73]. The graph is presented to show that predicted targets of Swi6 are highly interconnected to the known targets by a variety of methods, indicating possible functional relationships or physical interactions. The insert panel "a" shows and up-close schematic of the transcriptional feed-forward loop between Swi6, Rfx1, and YMR279C. Given the known functions of Rfx1, it is likely that Rfx1 represses the YMR279C gene.