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Fig. 6 | Biology Direct

Fig. 6

From: LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4

Fig. 6

Overexpression of LINC00909 promotes apoptosis in PDAC cells. (A) Flow cytometry was conducted to detect apoptosis after overexpression of LINC00909 in PANC-1 cells. (B, C) Flow cytometry was utilized to detect apoptosis after knockdown of LINC00909 in PANC-1 and BxPC-3 cells. (D) Western blotting was performed to examine the expression of BCL-2 and PUMA after overexpression of LINC00909 in PANC-1 cells. (E, F) Western blotting was performed to examine the expression of BCL-2 and PUMA after knockdown of LINC00909 in PANC-1 and BxPC-3 cells. P-values were assessed using two-tailed t-tests in (A–C). (***P < 0.001; ****P < 0.0001). BCL-2: B-cell lymphoma-2; LINC00909: Long intergenic non-protein coding RNA 00909; PDAC: Pancreatic ductal adenocarcinoma

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ISSN: 1745-6150

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