Fig. 11

A Representative images depict nude mice following subcutaneous injection of HCCLM3 cells (n = 6). B The tumor volume curves were plotted based on the measured tumor diameters. C Representative images depict the excised tumors following subcutaneous injection of HCCLM3 cells into nude mice. D Representative images depict the volume of the tumor at the time of excision. E Representative images depict nude mice following subcutaneous injection of Hep3B cells (n = 6). F The tumor volume curves were plotted based on the measured tumor diameters. G Representative images depict the excised tumors following subcutaneous injection of Hep3B cells into nude mice. H Representative images depict the volume of the tumor at the time of excision. I Immunofluorescence images of the subcutaneous tumor tissue show that STAMBPL1 and TRAF2 co-localize, and there is a significant positive correlation between the expression levels of TRAF2 and STAMBPL1. J Immunofluorescence images of the subcutaneous tumor tissue show that there is a significant positive correlation between the expression levels of β-catenin and STAMBPL1. K, L Immunohistochemistry experiments reveal a significant positive correlation between STAMBPL1 expression and the expression of Ki-67, PCNA, c-Myc, and β-catenin in subcutaneous tumor-bearing mice. M–O A xenograft tumor formation assay was conducted using HCCLM3 cells that were transfected with shControl, shSTAMBPL1, and subsequently reconstituted with TRAF2. M The tumors were visually represented in the provided gross images. N The growth curve of subcutaneous tumors in nude mice. O The weight of subcutaneous tumors in mice. P–R Hep3B cells were subjected to a xenograft tumor formation assay after transfection with either a vector or STAMBPL1, followed by reconstitution with sh-TRAF2. P The tumors were visually represented in the provided gross images. Q The growth curve of subcutaneous tumors in nude mice. R The weight of subcutaneous tumors in mice