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Fig. 7 | Biology Direct

Fig. 7

From: Circ_MAPK9 promotes STAT3 and LDHA expression by silencing miR-642b-3p and affects the progression of hepatocellular carcinoma

Fig. 7

Circ_MAPK9/miR-642b-3p/LDHA axis regulates aerobic glycolysis in HCC. A-B, ATP and lactic acid production in circ_MAPK9 knockdown HCC cells. C, The effect of circ_MAPK9 knockdown on the expression of glycolytic genes, analyzed by qRT-PCR. D, The effect of circ_MAPK9 knockdown on LDHA protein expression, analyzed by Western blot. E, Comparison of the luciferase activity of WT or MUT LDHA 3’UTR after treatment with miR-642b-3p mimics in HEK293T cells. F-G, The expression of LDHA mRNA and protein in SK-Hep1 cells transfected with miR-642b-3p mimics or inhibitor analyzed by qRT-PCR or Western blot, respectively. H, LDHA protein expression after transfection with circ_MAPK9 siRNA and/or miR-642b-3p inhibitor in SK-Hep1 cells, analyzed by Western blot

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Biology Direct

ISSN: 1745-6150

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