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Fig. 5 | Biology Direct

Fig. 5

From: Circ_MAPK9 promotes STAT3 and LDHA expression by silencing miR-642b-3p and affects the progression of hepatocellular carcinoma

Fig. 5

MiR-642b-3p acts as a tumor suppressor gene in HCC. A-B, The expression levels of miR-642b-3p in clinical HCC tissues and HCC cell lines. C, The expression correlation between circ_MAPK9 and miR-642b-3p in 41 pairs of HCC and corresponding non-tumor tissues was analyzed by Pearson correlation test (r = -0.326; P = 0.038). D, The overexpression efficiency of miR-642b-3p mimics in SMMC-7721 and SK-Hep1 cells detected by qRT-PCR. E, The knockdown efficiency of miR-642b-3p inhibitors in HCC cells detected by qRT-PCR. F, MiR-642b-3p overexpression significantly reduced the proliferative capacity of SMMC-7721 and SK-Hep1 cells determined by EdU and colony formation experiments. G, MiR-642b-3p knockdown significantly increased the proliferative capacity of SMMC-7721 and SK-Hep1 cells determined by EdU and colony formation experiments. *P < 0.05

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Biology Direct

ISSN: 1745-6150

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