Fig. 8

NRF1 promotes HCC metastasis in vivo. Lentivirus was used to establish stable NRF1 knockdown MHCC97H cell lines and tumor metastasis ability was assessed with tail vein injection model. A Lungs of the nude mice were excised and photographed. Arrows indicate metastasis loci. B Representative images of HE staining of the lungs to evaluate metastasis nodes. Arrows indicate metastasis loci. Scale bars: 1 mm. C The number of quantitative results of lung metastasis tumor. D The schematic of the present study. *p < 0.05, **p < 0.01, ***p < 0.001