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Fig. 3 | Biology Direct

Fig. 3

From: Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis

Fig. 3

NRF1 facilitates migration and invasion of HCC cells by regulating epithelial-mesenchymal transition. A-B Huh7 and MHCC97 cell migration (A) and invasion (B) ability were analysed by transwell assay after NRF1 knockdown or overexpression. Scale bar: 100 μm. The bar graph showed the relative cell number. C Huh7 and MHCC97H cell migration ability was analysed by wound healing assay after NRF1 knockdown or overexpression. Scale bar: 100 μm. The bar graphs showed the quantitative wound healing ability. D GSEA using EMT gene set between high NRF1 and low NRF1 group in TCGA-LIHC dataset. E Western blot showed the EMT related protein levels in Huh7 and MHCC97H after NRF1 knockdown or overexpression. *p < 0.05, ** p  < 0.01, *** p  < 0.001

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