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Fig. 7 | Biology Direct

Fig. 7

From: LY6/PLAUR domain containing 3 (LYPD3) maintains melanoma cell stemness and mediates an immunosuppressive microenvironment

Fig. 7

JUP/AGR2/LYPD3 signaling on melanoma cells promotes tumor growth and controls cytoskeletal remodeling. A–C In vivo experiments showed that overexpression of JUP significantly promoted tumor growth and that this effect could be attenuated by sh-LYPD3. D JUP/AGR2/LYPD3 signaling significantly promoted the expression of the key glycolytic enzyme GLUT1 in vivo. E–H JUP/AGR2/LYPD3 signaling significantly promoted the expression of the cytoskeletal protein F-actin in vivo (E, F) and had similar effects in vitro (G, H). One way ANOVA was conducted. I Phalloidin staining showed that JUP/AGR2/LYPD3 signaling remodelled the cytoskeleton and generated more pseudopod structures (yellow arrows). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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Biology Direct

ISSN: 1745-6150

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