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Fig. 7 | Biology Direct

Fig. 7

From: N6-methyladenosine methyltransferase KIAA1429 promoted ovarian cancer aerobic glycolysis and progression through enhancing ENO1 expression

Fig. 7

SPI1 promoted KIAA1429 transcription. A Venn diagram showing transcription factors that bind the promoter region of KIAA1429 identified in the GeneCards, JASPAR and TFtarget databases. B Effect of SPI1 or MAZ knockdown on KIAA1429 expression. n = 3 independent experiments. C ChIP analysis of SPI1 binding to the KIAA1429 promoter. The input and IgG served as positive and negative controls, respectively. n = 3 independent experiments. D Schematic of the putative SPI1 binding motif determined using JASPAR. E Cells were transfected with KIAA1429-WT or KIAA1429-MUT promoter constructs, and luciferase activity was analysed after transfection. n = 3 independent experiments; *P < 0.05, **P < 0.01, and ***P < 0.001

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Biology Direct

ISSN: 1745-6150

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