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Fig. 6 | Biology Direct

Fig. 6

From: Perilipin 5 deficiency aggravates cardiac hypertrophy by stimulating lactate production in leptin-deficient mice

Fig. 6

Plin5 deficiency exacerbated cardiac hypertrophy in leptin-deficient mice. A, B Lactate levels (A) and the expression of LDHA, CPT1, CPT2, PDH, pPDH (B) in the myocardial tissues of leptin-deficient (Plin5+/+/leptin−/−) and Plin5/leptin-double-knockout (DKO) mice (n = 3, *P < 0.05, ***P < 0.001). C–F Gross and histological features of the cardiomyocytes in Plin5/leptin single or double-knockout mice; a cross-section of the heart was taken for morphological observation. Scale bar, 50 μM. G Statistical analysis of the cross-sectional area of myocardium from Plin5/leptin single or double-knockout (DKO) mice (n = 4, *P < 0.01). H Expression of βMHC, in the myocardial tissues of Plin5/leptin-double-knockout mice (n = 3, ***P < 0.001). I mRNA levels of βMHC, ANF, and BNP in the Myocardial tissues of Plin5- and leptin-DKO mice as determined by qPCR. J–M Effect of Plin5 knockout on end-systolic variable in Plin5/leptin-knockout (Plin5+/+ or leptin−/−) or DKO mice

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