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Fig. 3 | Biology Direct

Fig. 3

From: Perilipin 5 deficiency aggravates cardiac hypertrophy by stimulating lactate production in leptin-deficient mice

Fig. 3

Plin5 deficiency promoted lactate production in cardiomyocytes. A The expression levels of PDH, pPDH and LDHA in the myocardia of wild-type (Plin5+/+) and Plin5-knockout (Plin5−/−) mice were analysed by Western blotting (n = 3, **P < 0.01). B Lactate levels in the myocardia of Plin5+/+ and Plin5−/− mice (n = 3, **P < 0.05). C After treatment with FAs, the expression levels of PDH, pPDH and LDHA were analysed by Western blotting in Plin5+/+ and Plin5−/− neonatal mouse cardiomyocytes (n = 3, *P < 0.05, **P < 0.01). D The lactate content was also determined (n = 3, *P < 0.05). E, F Expression of PDH, pPDH and LDHA (E) (n = 3, *P < 0.05, **P < 0.01) and lactate production (F) in control (EV) and Plin5-overexpressing (Plin5) H9C2 cells treated with FAs (n = 3, *P < 0.05)

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