METTL3-induced lncRNA GBAP1 promotes hepatocellular carcinoma progression by activating BMP/SMAD pathway

Biology Direct

Table 1 Correlation between GBAP1 expression and the clinicopathologic characteristics in HCC

Characteristics	Cases (n = 85)	Expression of GBAP1		P
Characteristics	Cases (n = 85)	High (n = 42)	Low (n = 43)	P
Age (year)
< 50	27	12	15	0.532
≥ 50	58	30	28
Gender
Male	72	34	38	0.342
Female	13	8	5
HBV
Absent	12	9	3	0.056
Present	73	33	40
Serum AFP level (ng/mL)
< 400	21	14	7	0.068
≥ 400	64	28	36
Tumor size (cm)
< 5	39	14	25	0.022*
≥ 5	46	28	18
Number of tumor nodules
1	70	32	38	0.141
≥ 2	15	10	5
Cirrhosis
Absent	23	8	15	0.100
Present	62	34	28
Venous infiltration
Absent	61	26	35	0.046*
Present	24	16	8
Edmondson–Steiner grading
I + II	56	24	32	0.093
III + IV	29	18	11
TNM stage
I + II	63	27	36	0.041*
III + IV	22	15	7

*P < 0.05
HCC hepatocellular carcinoma, HBV hepatitis B virus, AFP alpha-fetoprotein, TNM tumor-node-metastasis

ISSN: 1745-6150