Did the early full genome sequencing of yeast boost gene function discovery?

Biology Direct

Table 4 Years necessary to generate a literature body of given FPE intervals about a S. cerevisiae gene

The letter “T” in abbreviations “T0, T1, etc.” stands for “threshold” applied to FPE values (compare with Table 2). We list the minimal (Min), maximal (Max), median and mean (together with the respective standard deviation—SD) numbers of years needed to accumulate the necessary FPEs for a given gene relative to the gene’s year for T0. As the research technology has dramatically improved compared with the time when the first genes achieved T0 (the first relevant recorded publication PMID:19872702 about invertase is from 1932), we also give the data for all eligible yeast genes as well as separately for those with their T0 event beginning with 1965 (molecular biology got established), with 1989 (gene sequencing became routine) and after 2000 (omics technologies got widely available). Notably, the years necessary for getting into higher T ranges tend to get smaller for more recently studied genes but still remain well above a decade (~ 15 years). Notably, the median number of years needed to make a threshold dropped more dramatically for higher literature thresholds (> 15 years for T75, T100 and T500 versus a drop by just 5–10 years for medium T-thresholds). The data emphasizes that, indeed, technological developments such as the introduction of omics technologies had a positive effect on the progress in gene function discovery

ISSN: 1745-6150