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Fig. 7 | Biology Direct

Fig. 7

From: USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice

Fig. 7

Inhibitors of p38/NCOA3/p300 decreased the expression of ADAMTS genes and slowed the degeneration of IVDs in LPS-challenged mice

(A) The injection time points for LPS and p38/NCOA3/p300 inhibitors. (B) Representative MRI images of lumbar IVDs from different groups of mice. (C) Representative picrosirius red staining images of IVDs from different groups of mice. Bars = 100 μm. (D-G) Serum concentrations of proinflammatory cytokines: IL-1β (D), IL-6 (E), IL-15 (F), and TNFα (G). (H-M) The mRNA expression levels of ADAMTS genes in different groups of mice (n = 8 for each group). (H)ADAMTS1; (I)ADAMTS2; (J)ADAMTS3; (K)ADAMTS4; (L)ADAMTS5; (M)ADAMTS6; *P < 0.05; **P < 0.01; ***P < 0.001; ns: no significant difference

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