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Fig. 1 | Biology Direct

Fig. 1

From: USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice

Fig. 1

Chronic inflammation promoted the degeneration of IVDs and induced ADAMTS levels in LPS-challenged mice

(A) Time points of LPS injection. (B-E) Serum concentrations of proinflammatory cytokines: IL-1β (B), IL-6 (C), IL-15 (D), and TNFα (E). (F-N) The mRNA expression levels of ADAMTS genes in sham- and LPS-treated mice (n = 8). (F)ADAMTS1; (G)ADAMTS2; (H)ADAMTS3; (I)ADAMTS4; (J)ADAMTS5; (K)ADAMTS6; (L)ADAMTS7; (M)ADAMTS8; (N)ADAMTS9. (O) Representative MRI images of lumbar IVDs from sham- and LPS-treated mice. (P) Representative picrosirius red staining images of IVDs from sham- and LPS-treated mice. Bars = 100 μm. *P < 0.05; **P < 0.01; ***P < 0.001; ns: no significant difference

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