Fig. 3
From: Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
Strategies to rejuvenate aged MSCs
Aged MSCs suitable for treatment can be obtained by sorting surface markers. Senescent MSCs can be deleted with senolytics. Pretreatment can be performed with several reagents able to target the AMPK signalling pathway, ROS and autophagy factors to rejuvenate aged MSCs. Gene modification for inducing the upregulation or knocking down some target genes favours aged MSC rejuvenation