Fig. 1
From: Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
Characteristics of aged MSCs
With ageing, MSCs express many senescence markers, including an enlarged and flattened cell shape, upregulation of p53, p21, and p16 expression, increased activation of beta-galactosidase, and increased miR-335 expression in MVs. Ageing suppressed some basic functions of MSCs, including their proliferation, CFU formation, migration and homing. Aged MSCs also present a skewed trilineage differentiation pattern, with enhanced adipogenesis and reduced osteogenesis and chondrogenesis rates