Fig. 3
From: Pro-tumorigenic role of lnc-ZNF30-3 as a sponge counteracting miR-145-5p in prostate cancer
Lnc-ZNF30-3 is upregulated in PCa tumor tissues and potentially correlates with poor-prognosis PCa patients. A. RNA-seq profiling of lnc-ZNF30-3 in normal and tumor tissues along sense (blue) and antisense (pink) strands of chromosome 19. B. Violin diagram of log2(RPKM) counts of lnc-ZNF30-3 expression in prostate cancer tumor (orange) and normal (blue) tissues of the TCGA-PRAD cohort. Horizontal bars correspond to a mean value. P-value (9.5 × 10− 18) was calculated using a Wilcoxon test. C. Kaplan-Meier estimation of the PCa patients’ survival related to lnc-ZNF30-3 expression, done using the TANRIC platform and TCGA datasets (P-value 0.11385). D. Mapping of potential miR-145 REs along the longest lnc-ZNF30-3 isoform of 5,394 nucleotides. MiR-145-5p 6mer refers to conventional RE sequence (ACUGGA), 7mer.A1 refers to ACUGGAA, 7mer.m8.GU refers to GACUGGA. MiR-145-3p 7mer.m8 refers to GGGAAUC. E. Venn diagram representing miRNAs experimentally shown to target TWIST1/2, ZEB1/2, SNAIL1/2 transcription factors, and putative RE within lnc-ZNF30-3.