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Fig. 4 | Biology Direct

Fig. 4

From: Dynamic expression of IGFBP3 modulate dual actions of mineralization micro-environment during tooth development via Wnt/beta-catenin signaling pathway

Fig. 4

Bioinformatics analysis identifying differentially expressed genes (DEGs) between IGFBP3-over and lv5 hDPSCs. A DEGs between IGFBP3-over and lv5 hDPSCs were identified by RNA-seq analysis (a). KEGG pathway enrichment analysis revealed Wnt signaling pathway exhibited the highest enrichment score (b). The subsets of Wnt signaling pathway related genes in RNA-seq data were compared in terms of their expression levels and at the top of the list is Dickkopf related protein 1 (c). B Relative expression of GSK3β and DKK1 in lv5 and IGFBP3-over hDPSCs were detected by RT-qPCR (a). The protein levels of IGFBP3 and DKK1 in lv5 and IGFBP3-over hDPSCs were detected by Western blot analysis (b1), with quantitative analysis of the relative protein expression (b2)

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