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Fig. 4 | Biology Direct

Fig. 4

From: Single-cell transcriptomics reveals cellular heterogeneity and macrophage-to-mesenchymal transition in bicuspid calcific aortic valve disease

Fig. 4

Re-clustering of immune cells in BAV. (a) UMAP plot showing 6 subclusters of lymphocytes. Data represent n = 2590 lymphocytes. (b) Visualization of 3D projection of UMA plot. (c) The distribution of lymphatic subclusters in specimens. (d) Top 5 marker genes of lymphatic subclusters generated using Seurat. (e) Spearman correlation analysis of lymphatic transcriptomes based on top 1000 highly variable genes. (f) GO enrichment analysis of lymphatic subclusters. (g) Selected markers for each subcluster represented as dot plot. (h) UMAP plot showing 6 subclusters of monocytic cells. Data represent n = 8063 monocytic cells. (i) Visualization of 3D projection of UMA plot. (j) The distribution of each subcluster in specimens. (k) Spearman correlation analysis based on top 1000 highly variable genes. (l) Stacked violin plot showing selected marker genes of each monocytic subcluster. (m) GSEA plots showing ECM organization and calcification related processes were activated in ACTA2+MDSC (sC3)

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Biology Direct

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