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Fig. 3 | Biology Direct

Fig. 3

From: Single-cell transcriptomics reveals cellular heterogeneity and macrophage-to-mesenchymal transition in bicuspid calcific aortic valve disease

Fig. 3

Functional diversity of endothelial cells. (a) UMAP plot showing 4 subclusters of EC. Data represent n = 535 ECs. (b) Visualization of 3D projection of UMAP plot. (c) The distribution of each subcluster in specimens. (d) Spearman correlation analysis based on top 1000 highly variable genes. (e) Enriched KEGG pathways in different subclusters. (f) GSEA plots showing biological process of angiogenesis was activated in sC2. (g) GSEA plots showing biological process of blood coagulation was activated in sC3. (h) Dotplot showing selected marker genes of each EC subcluster. (i-j) Trajectory and pseudotime of ECs on DDRTree projection (inferred using Monocle2). (k) EndMT related genes were upregulated in cell fate 1

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Biology Direct

ISSN: 1745-6150

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