Skip to main content
Fig. 2 | Biology Direct

Fig. 2

From: Single-cell transcriptomics reveals cellular heterogeneity and macrophage-to-mesenchymal transition in bicuspid calcific aortic valve disease

Fig. 2

Subcluster of stromal cells in BAV. (a) UMAP projection showing 13 subclusters of stromal cells (VICs and EC), and cell distribution in different specimen. Data represent n = 30,531 stromal cells. (b) Visualization of 3D projection of UMA plot. (c) Spearman correlation analysis based on top 1000 highly variable genes. (d) Stacked violin plot showing selected marker genes of each monocytic subcluster. (e) RNA velocity plot of stromal cells and (f) cellular latent time calculated via dynamic modeling. (g) GSEA plots indicated calcification associated processes were activated in POSTN+VIC (sC6). (h) Dot plot of GSEA results indicated response to interleukin-1 were activated in CCL2+VIC (Sc7). (i) GSEA plots indicated angiogenesis associated processes were activated in RGS5+VIC (sC9)

Back to article page

Biology Direct

ISSN: 1745-6150

Contact us