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Fig. 1 | Biology Direct

Fig. 1

From: Single-cell transcriptomics reveals cellular heterogeneity and macrophage-to-mesenchymal transition in bicuspid calcific aortic valve disease

Fig. 1

scRNA-seq and major cellular constitution of human stenotic BAV tissues. (a) scRNA-seq experiment used 4 specimens (1 non-calcified and 3 calcified specimens) surgically removed from aortic valve stenosis patients with BAV. (b) UMAP plot from scRNA-seq data of 4 specimens surgically removed from aortic valve stenosis patients. Data represent n = 41,305 cells. We found 5 major cell types: valvular interstitial cells (VIC), monocytic cells, lymphocytes, endothelial cells (EC), mast cells (Mast). (c) Expression patterns of selected markers to annotate major cell types. (d-e) The distribution of each subcluster in specimens. (f) Important markers of major cell types presented as feature plot (COL3A1 for VIC, PECAM1 for EC, CD14 for monocytic cells, CD3D for lymphocytes and CPA3 for mast cells)

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Biology Direct

ISSN: 1745-6150

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