Fig. 2

Synapse diversity resides in specific functions and cellular compartments. For all SynGO categories, the mean AUROC score across the 16 cell types is shown for biological functions (A) and cellular compartments (C) annotated in SynGO. Some SynGO terms (red) perform better than random synaptic gene sets of the same size (black line). Randomly generated synaptic gene sets (black line) discriminate cell types better than random gene sets (grey line) regardless the set size (Wilcoxon rank sum test; W = 3049, p = 0.001). The sunburst plots show the SynGO biological processes (B) and cellular compartments (D) where most variability lies across all neuronal subclasses. The color code (p value) indicates SynGO terms that perform significantly better than random synaptic gene sets of the same size