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Fig. 6 | Biology Direct

Fig. 6

From: USP5 knockdown alleviates lung cancer progression via activating PARP1-mediated mTOR signaling pathway

Fig. 6

USP5 promotes the progression of lung cancer by targeting PARP1 in vitro and vivo. (A) Western blots showed that PARP1 was efficiently knocked down in USP5 overexpressed lung cancer cells. (B-D) Effect of PARP1 knockdown on the proliferation, colony formation, and migration abilities of USP5 overexpressing lung cancer cells. (E-F) Role of PARP1 inhibitors on colony formation, and migration abilities of USP5 overexpressing cells. (G) Effect of PARP1 knockdown on the volume of subcutaneous tumor in mice. * P < 0.05, ** P < 0.01, *** P < 0.001

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Biology Direct

ISSN: 1745-6150

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