circACTR2 attenuates gemcitabine chemoresiatance in pancreatic cancer through PTEN mediated PI3K/AKT signaling pathway

Table 2 Univariate and multivariate Cox regression analysis of circACTR2 and survival in patients with PC

Clinicopathological variables	Univariate analysis	P	Multivariate analysis	P
Clinicopathological variables	HR (95% CI)	P	HR (95% CI)	P
Age (> 60 vs. ≤ 60)	0.785(0.497–1.240)	0.299
Gender (Male vs. Female)	0.887(0.550–1.432)	0.624
Tumor location (Head vs. Body/tail)	0.916(0.577–1.454)	0.710
Pathological grade (І-ІІ vs. III)	0.515(0.321–0.828)	0.006*	0.530(0.326–0.862)	0.010*
T stage (T1/T2 vs. T3/T4)	1.080(0.603–1.935)	0.795
N stage (N0 vs. N1)	0.576(0.362–0.915)	0.019*
TNM stage (І vs. II)	0.583(0.360–0.944)	0.028*	0.474(0.287–0.782)	0.003*
circACTR2 (High vs. Low)	0.178(0.105–0.304)	< 0.001*	0.170(0.098–0.296)	< 0.001*

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