Fig. 6From: circACTR2 attenuates gemcitabine chemoresiatance in pancreatic cancer through PTEN mediated PI3K/AKT signaling pathwayTargeting circACTR2 in vivo retards PC GEM resistanceA Tumor volume was measured every four days in OE-circ and OE-NC groups after the gemcitabine injections (n = 4). B Pictures of tumors and C tumors weight in OE-circ and OE-NC groups 4 weeks after the GEM treatment. Immunohistochemical staining of PCNA D and tunnel E in OE-circ and OE-NC group tumors (×200). Percentage of PCNA-positive and tunnel-positive cells was shown for each group. *P < 0.05; **P < 0.01Back to article page