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Fig. 8 | Biology Direct

Fig. 8

From: Upregulation of long intergenic non-coding RNA LINC00326 inhibits non-small cell lung carcinoma progression by blocking Wnt/β-catenin pathway through modulating the miR-657/dickkopf WNT signaling pathway inhibitor 2 axis

Fig. 8

LINC00326 downregulation accelerates tumor growth in vivo. a Appearance of tumors four weeks after injection, showing the blank control, negative control, LINC00326 overexpression, shCTRL, and LINC00326 knockdown. b Tumor volumes in the five groups (mean ± SD) at time of sacrifice. c, d LINC00326 and miR-657 mRNA expression in tumors from blank, OE-CTRL, OE- LINC00326, shCTRL, and shLINC00326 groups. e Wnt1, Wnt3A, and β-catenin protein levels in tumors from blank, OE-CTRL, OE- LINC00326, shCTRL, and shLINC00326 groups. f–h Ki67 and TUNEL staining in blank, OE-CTRL, OE- LINC00326, shCTRL, and shLINC00326 groups, respectively (× 200, scale bars, 100 µm); n = 3. Data are presented as mean ± SEM; *P < 0.05; **P < 0.01; ***P < 0.001

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Biology Direct

ISSN: 1745-6150

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