Artificial genetic polymers against human pathologies

Biology Direct

Table 1 Effects of backbone modifications on some functional properties of nucleic acids

Modification	Duplex stability	Hybridization specificity	Sensitivity to pH changes	Sensitivity to ionic strength	Solubility	RNAse resistance	RNAse H activation
PNA	↓	↑	↓	↓	↓	↑	↓
LNA	↑	↑	↓	↓	↓	↑	↓
PSO	↓	N/A	N/A	N/A	↓	↑	N/A
MOE, 2’-O-Me	↑	N/A	N/A	N/A	↑	↑	N/A
2’-F,2’-deoxy	↑	N/A	N/A	N/A	↑	↑	N/A
Triazole-linked	↓	N/A	N/A	N/A	N/A	↑	N/A

↑ and ↓ indicate increase or decrease with respect to unmodified DNA or RNA, reviewed in more detail in [70]

ISSN: 1745-6150