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Fig. 6 | Biology Direct

Fig. 6

From: N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway

Fig. 6

miR-139-5p negatively regulated the expression of the target gene CTBP1. A Correlation analysis of CTBP1 and miRNA-139-5p. B, C A dual luciferase reporter assay was conducted to determine the relative luciferase activities following the indicated transfections in H293T and MIA Paca-2 cells. D, E CTBP1 was downregulated following miRNA-139-5p overexpression in BxPC-3 and MIA Paca-2 cells and overexpressed following silencing of miRNA-139-5p in PANC-1 cells. F–H CTBP1 protein expression was detected following the indicated transfections in BxPC-3, MIA Paca-2, and PANC-1 cells. Data are shown as the mean ± SD. *P < 0.05; **P < 0.01

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Biology Direct

ISSN: 1745-6150

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