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Fig. 1 | Biology Direct

Fig. 1

From: N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway

Fig. 1

SH3BP5-AS1 was upregulated in GEM-treated PDX pancreatic cancer and its upregulation was negatively correlated with overall survival. A Establishment of the PDX pancreatic cancer model and experimental workflow of GEM treatment. B Heatmap displaying the top 10 upregulated lncRNAs in GEM-treated and control PDX mice. C Correlation analysis of SH3BP5-AS1 and clinicopathological features based on the TCGA database. D SH3BP5-AS1 was upregulated in pancreatic cancer tumor tissues compared with the paired adjacent tissues, as revealed by RT-qPCR. E SH3BP5-AS1 is an independent risk factor for the prognosis of pancreatic cancer, as revealed by ROC curve analysis. F Upregulation of SH3BP5-AS1 was correlated with poor overall survival. G SH3BP5-AS1 expression was significantly higher in pancreatic cancer cells compared with HPDE6-C7 cells. Data are shown as the mean ± SD. *P < 0.05; **P < 0.01

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Biology Direct

ISSN: 1745-6150

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