Fig. 2
From: Long non-coding RNAs affecting cell metabolism in cancer
Regulation of mitochondrial activity and lipid metabolism by LncRNA in breast cancer. Energy–stress induces the expression of GAS5, which in turn inhibits the interaction between of FH, MDH2 and CS. This results in the reduction of TCA flux. The lncRNA NEAT stimulate the use of free fatty acids as energy source in breast cancer. NEAT1, sponging miR107, up regulates CPT1A expression in breast cancer cells. Competing with miR34a-5p and miR204-5p NEAT1 also controls the expression of ACSL4. TCA: Tricarboxylic acid; FH: Fumarate hydratase; CS: Citrate synthase; MDH2: Malate dehydrogenase; FAO: Fatty acid oxidation; ACSL4: Acyl-CoA Synthetase Long Chain Family Member 4; CPT1: Carnitine Palmitoyltransferase 1