Fig. 1

LncRNA regulates glycolysis in breast cancer cells. A YAP regulate the expression of the lncRNA BCAR4, which in turn by interacting with GLI2, promotes the transcription of two enzymes, HK2 and PFKFB3, resulting in the upregulation of the glycolytic pathway. B Under hypoxic conditions the LncRNA HIFAL is essential for maintaining HIF-1α transactivation and stimulates glycolysis in breast cancer cells by regulating the expression of glycolytic genes. HK-2: hexokinase 2; PFKB3: 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3; GLUT1: Glucose Transporter 1; LDHA: Lactate Dehydrogenase A; PDK1: Pyruvate Dehydrogenase Kinase 1; GLI2: GLI Family Zinc Finger 2