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Table 1 COGs that are among hypervariable families among both bacteria and archaea

From: Analysis of lineage-specific protein family variability in prokaryotes combined with evolutionary reconstructions

COG number Function Gene name Description Number of csCOGs*
Deinococcus-V1 Deinococcus-V2 Flavobacteriales—V1 Flavobacteriales—V2 Haloferacales—V1 Haloferacales—V2 Methanosarcinales—V1 Methanosarcinales—V2
COG0438 M RfaB Glycosyltransferase involved in cell wall biosynthesis 6 5 14 10 8 4 4 10
COG0456 J RimI Ribosomal protein S18 acetylase RimI and related acetyltransferases 10 3 7 7 15 2 5 3
COG0463 M WcaA Glycosyltransferase involved in cell wall biosynthesis 2 1 12 5 8 2 5 3
COG0531 E PotE Serine transporter YbeC, amino acid:H + symporter family 0 0 4 1 1 1 5 1
COG0671 I PgpB Membrane-associated phospholipid phosphatase 2 1 3 1 1 1 0 1
COG0747 E DdpA ABC-type transport system, periplasmic component 9 1 1 0 3 3 1 1
COG0842 V YadH ABC-type multidrug transport system, permease component 2 0 4 2 1 1 2 2
COG1131 V CcmA ABC-type multidrug transport system, ATPase component 5 1 8 1 8 1 3 2
COG1216 G WcaE Glycosyltransferase, GT2 family 0 1 6 1 0 2 0 1
COG1846 K MarR DNA-binding transcriptional regulator, MarR family 9 3 3 1 6 2 7 1
COG2226 H UbiE Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG 8 3 3 2 16 2 14 7
COG2244 M RfbX Membrane protein involved in the export of O-antigen and teichoic acid 1 2 4 2 0 2 6 4
COG2814 G AraJ Predicted arabinose efflux permease AraJ, MFS family 23 4 3 3 18 2 6 2
COG number Function Gene name Description Number of csCOGs*
Paenbacillus—V1 Paenbacillus—V2 Rhodococcus—V1 Rhodococcus—V2 Sulfolobales—V1 Sulfolobales—V2 Thermococcales—V1 Thermococcales—V2
COG0438 M RfaB Glycosyltransferase involved in cell wall biosynthesis 23 6 7 4 11 3 3 5
COG0456 J RimI Ribosomal protein S18 acetylase RimI and related acetyltransferases 31 13 9 2 2 1 7 0
COG0463 M WcaA Glycosyltransferase involved in cell wall biosynthesis 16 4 3 3 2 4 7 2
COG0531 E PotE Serine transporter YbeC, amino acid:H + symporter family 9 4 4 2 17 3 0 1
COG0671 I PgpB Membrane-associated phospholipid phosphatase 6 1 3 1 1 0 2 1
COG0747 E DdpA ABC-type transport system, periplasmic component 4 2 2 4 2 2 2 1
COG0842 V YadH ABC-type multidrug transport system, permease component 8 2 6 2 7 2 5 1
COG1131 V CcmA ABC-type multidrug transport system, ATPase component 24 5 15 0 11 2 6 3
COG1216 G WcaE Glycosyltransferase, GT2 family 7 0 8 1 1 2 1 2
COG1846 K MarR DNA-binding transcriptional regulator, MarR family 23 5 16 8 4 3 2 0
COG2226 H UbiE Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG 20 6 13 5 7 1 2 4
COG2244 M RfbX Membrane protein involved in the export of O-antigen and teichoic acid 7 2 2 3 4 1 2 3
COG2814 G AraJ Predicted arabinose efflux permease AraJ, MFS family 38 7 46 10 10 3 13 1
  1. *V1—low and medium variability csCOGs; V2—high variability csCOGs; Haloferacales family, Sulfolobales family, Thermococcales family, Methanosarcinales family and bacteria—Flavobacteriales family, Deinococcus genus, Paenbacillus genus, Rhodococcus genus