Skip to main content

Table 5 Other outcomes

From: Total neoadjuvant therapy for the treatment of locally advanced rectal cancer: a systematic minireview

Study

ARMS (N patients)

DFS

OS

Compliance**

AEs*

Post-operative complications

LCRT

TNT

EudraCT

EXP. ARM (28)

–

–

23 (86%)

27 (95%)

10 (36%)

7 (25%)

CONTROL (29)

28 (97%)

–

2 (7%)

9 (31%)

GCR-3

EXP. ARM (56)

62%1

75%1

42 (78%)

51 (94%)

12 (23%)

27 (51%)

CONTROL (52)

64%1

78%1

46 (94%)

–

15 (29%)

21 (45%)

POLISH II

EXP. ARM (261)

53%2

73%2

–

23%

29%

CONTROL (254)

52%2

65%2

21%

25%

WAIT

EXP. ARM (25)

–

–

–

–

–

CONTROL (24)

KCSG CO 14-03

EXP. ARM (53)

–

–

–

5 (9%)

4 (9%)

CONTROL (55)

2 (4%)

1 (2%)

FOWARC

ARM TNT + RT (165)

78%2

90%2

–

–

–

ARM TNT (165)

74%2

91%2

CONTROL (165)

73%2

91%2

RAPIDO

EXP. ARM (462)

â‚®

89%2

–

84%

–

50%

CONTROL (450)

89%2

93%

–

47%

PRODIGE-23

EXP. ARM (231)

76%2

91%2

219 (95%)

 > 90%

73 (45%)

–

CONTROL (230)

69%2

88%2

227 (99%)

–

117 (74%)

  1. DFS: Disease Free Survival; OS: Overall Survival; AEs: Adverse Effects
  2. *Grade III/IV AEs; Compliance to the treatment is defined as administration of at least the 75% of the described dose
  3. DrTF 30% versus 24% in the experimental and standard arms, respectively
  4. 1Results at five-years
  5. 2Results at three-years