An integrative in-silico analysis discloses a novel molecular subset of colorectal cancer possibly eligible for immune checkpoint immunotherapy

Table 3 Records of the cosine similarity between the three mutational signatures extracted from each group from the MAF files and the three most similar COSMIC mutational signatures

	SBS best match	Aetiology	Cosine similarity
HM
Signature 1	SBS44	Defective DNA mismatch repair	0.81
Signature 2	SBS10b	Polymerase epsilon exonuclease domain mutations	0.78
Signature 3	SBS6	Defective DNA mismatch repair	0.90
HM-like
Signature 1	SBS1	Spontaneous or enzymatic deamination of 5-methylcytosine	0.94
Signature 2	SBS30	Deficiency in base excision repair due to inactivating mutations in NTHL1	0.83
Signature 3	SBS6	Defective DNA mismatch repair	0.93
Non-HM
Signature 1	SBS1	Spontaneous or enzymatic deamination of 5-methylcytosine	0.96
Signature 2	SBS40	Unknown	0.89
Signature 3	SBS6	Defective DNA mismatch repair	0.77

In the table are reported the best matches between the three mutational signatures extracted from the three groups and the COSMIC SBS Signatures database

ISSN: 1745-6150