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Table 3 Records of the cosine similarity between the three mutational signatures extracted from each group from the MAF files and the three most similar COSMIC mutational signatures

From: An integrative in-silico analysis discloses a novel molecular subset of colorectal cancer possibly eligible for immune checkpoint immunotherapy

  SBS best match Aetiology Cosine similarity
HM    
 Signature 1 SBS44 Defective DNA mismatch repair 0.81
 Signature 2 SBS10b Polymerase epsilon exonuclease domain mutations 0.78
 Signature 3 SBS6 Defective DNA mismatch repair 0.90
HM-like    
 Signature 1 SBS1 Spontaneous or enzymatic deamination of 5-methylcytosine 0.94
 Signature 2 SBS30 Deficiency in base excision repair due to inactivating mutations in NTHL1 0.83
 Signature 3 SBS6 Defective DNA mismatch repair 0.93
Non-HM    
 Signature 1 SBS1 Spontaneous or enzymatic deamination of 5-methylcytosine 0.96
 Signature 2 SBS40 Unknown 0.89
 Signature 3 SBS6 Defective DNA mismatch repair 0.77
  1. In the table are reported the best matches between the three mutational signatures extracted from the three groups and the COSMIC SBS Signatures database
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Biology Direct

ISSN: 1745-6150

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