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Fig. 2 | Biology Direct

Fig. 2

From: An integrative in-silico analysis discloses a novel molecular subset of colorectal cancer possibly eligible for immune checkpoint immunotherapy

Fig. 2

Unsupervised hierarchical clustering analysis based on CNVs data of the 520 CRC patients selected from TCGA-COAD and READ projects. The lines in the heatmap represent significant focal alteration. The columns correspond to the 520 patients. HM and non-HM samples are indicated in yellow and blue colors, respectively. This analysis identified two main clusters: cluster a (ClA) and cluster b (ClB). ClA (117/520; 22.5%) is characterized by a few events of CNVs along the chromosome regions and was enriched in HM samples (n = 76/117; 63.9%). ClB contains samples with a high number of CNVs events and it mostly consists of non-HM samples (n = 401/403; 99%). Among ClA, we identified a sub-group of tumors (called HM-like; n = 41/520; 7.8%) with a similar CNV profile of ClA, also characterized by a low TMB. To the right-hand side of the figure, a scale indicates the color code relative to the log2 segment mean value of CNVs (ranging from − 1 up to 3)

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Biology Direct

ISSN: 1745-6150

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