Table 1 Characteristics of migrasomes

MIGRASOMES FEATURES

SIZE

0.5–3 μm

MARKERs

TSPAN4, Integrin 5α, CPQ, NDST1, PIGK, EOGT, WGA

CONTENTS

Chemokines, Cytokines, Growth factors, mRNAs, proteins, Damaged Mitochondria

LIPIDS

Cholesterol

ORIGIN

After the Retraction Fibers (RFs) break

MECHANISM OF RELEASE

Self organization of tetraspanins and cholesterol in macrodomains (TEMAs), during cell migration

DETECTION METHODS

Electron microscopy, WB for specific migrasomes markers, Immunofluorescence, Live-imaging

ISOLATION METHODS

Ultracentrifugation

REFERENCES

[4, 5, 7, 25, 27,28,29,30,31, 33,34,35,36, 36, 37, 43, 44]