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Fig. 5 | Biology Direct

Fig. 5

From: LncRNA MIR205HG accelerates cell proliferation, migration and invasion in hepatoblastoma through the activation of MAPK signaling pathway and PI3K/AKT signaling pathway

Fig. 5

MiR-514a-5p down-regulation or MAPK9 up-regulation partially restores the suppressive role of MIR205HG insufficiency in HB progression. A MAPK9 was overexpressed in HepG2 cells. B–C Cell proliferation was observed in HepG2 cells in the sh-NC group, sh-MIR205HG#1 group, sh-MIR205HG#1 + miR-514a-5p inhibitor group and sh-MIR205HG#1 + pcDNA3.1/MAPK9 group. D Wound healing assay assessed cell migration in the sh-NC group, sh-MIR205HG#1 group, sh-MIR205HG#1 + miR-514a-5p inhibitor group and sh-MIR205HG#1 + pcDNA3.1/MAPK9 group. E–F Cell migration and invasion were appraised in different groups through transwell assays. GAPDH and U6 were used as internal references for RT-qPCR. Each experiment was performed in triplicate. Student’s t-test and one-way ANOVA were adopted for statistics. *P < 0.05, **P < 0.01

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