Fig. 4
From: Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer
The main PDZ-containing proteins of a glutamatergic synapse are highlighted. PDZ domains are indicated by yellow circles while SH3 and GK domains are represented as orange squares and green rhombuses, respectively. All the other proteins are shown as simple shapes and are labelled. A subset of known protein–protein interactions is illustrated. Ca Ch, calcium channel; nNOS, neuronal nitric oxide synthase; GKAP, guanylate kinase-associated protein; K Ch, potassium channel; SHANK, SH3 and ankyrin repeat-containing protein; IP3R, IP3 receptor; SER, smooth endoplasmic reticulum; PSD-95, postsynaptic density protein 95; NMDAR, NMDA (N-methyl-D-aspartate) receptor; AKAP79, A-kinase anchor protein. (Figure designed through BioRender.com online tool)